Cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest

Journal of Natural Products
Shugeng CaoDavid G I Kingston

Abstract

Bioassay-guided fractionation of the cytotoxic MeOH extract obtained from Acridocarpus vivy led to the isolation of five new triterpenoids, acridocarpusic acids A-E (1-5); three known triterpenoids, moronic acid (6), ursolic acid, and oleanolic acid; and two known flavonoids, 4',5-dihydroxy-7-methoxyflavone and 4',5-dihydroxy-3',7-dimethoxyflavone. The structures of the new compounds 1-5 were established on the basis of extensive 1D and 2D NMR spectroscopic data interpretation. Compound 3 showed significant cytotoxic activity in the A2780 assay, with an IC50 value of 0.7 microg/mL.

References

Jun 8, 2000·Journal of Natural Products·K KinoshitaH Yuasa
Feb 14, 2003·Evolution; International Journal of Organic Evolution·Charles C DavisSarah Mathews

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Citations

Mar 29, 2007·Natural Product Reports·Joseph D Connolly, Robert A Hill
Mar 1, 2012·Natural Product Research·Sugey López-MartínezMaría Yolanda Rios
Mar 27, 2009·BMC Complementary and Alternative Medicine·Ramzi A MothanaPatrick J Bednarski
Dec 9, 2009·Antiviral Research·Fang-Rong ChangLi-Kwan Chang
Sep 18, 2007·Phytochemistry·Keller Guilherme GuimarãesFernão Castro Braga
May 21, 2013·Journal of Ethnopharmacology·Ilaine T S GehrkeAdemir F Morel
Jul 23, 2014·BMC Complementary and Alternative Medicine·Glauco Morales, Adrián Paredes
Dec 3, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Silvia Bruni, Vittoria Guglielmi
Nov 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sameera Omar Mohammed Saeed BalhamarFarah Mustafa

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