Cytotoxic triterpenoids from the root bark of Helicteres angustifolia

Chemistry & Biodiversity
Min-Hsiung PanZong-Tsi Chen

Abstract

Three new triterpenoids, 3beta-acetoxy-27-[(E)-cinnamoyloxy]lup-20(29)-en-28-oic acid methyl ester (1), 3beta-acetoxy-27-[(4-hydroxybenzoyl)oxy]lup-20(29)-en-28-oic acid (2), and 3beta-acetoxy-27-[(4-hydroxybenzoyl)oxy]olean-12-en-28-oic acid methyl ester (3), together with nine known triterpenoids, 4-12, were isolated from the root bark of Helicteres angustifolia. The structures of these compounds were established on the basis of spectroscopic methods including 2D-NMR experiments. All twelve compounds were tested for their cytotoxic activities against human colorectal cancer (COLO 205), human hepatoma (Hep G2), and human gastric cancer (AGS) cell lines in vitro. Among them, compounds 2, 3, 3beta-O-[(E)-coumaroyl]betulinic acid (6), and pyracrenic acid (7) showed significant cytotoxic activities against human cancer cells COLO 205 and AGS.

References

Jul 1, 1992·Journal of Natural Products·M A RashidJ A Armstrong
May 1, 1985·Journal of Natural Products·M F BeanJ M Cassady
Mar 17, 1999·Journal of Natural Products·C I Chang, Y H Kuo
May 31, 2001·Phytochemistry·K KamiyaT Satake
Oct 16, 2001·Journal of Pharmaceutical and Biomedical Analysis·Y S ChangL K Ho
Jul 20, 2002·Journal of Ethnopharmacology·Ranjan ChakrabartiR Rajagopalan
Nov 23, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M C T TruitiM C Souza
Jan 7, 2006·Phytotherapy Research : PTR·Young-Won ChinA Douglas Kinghorn
Feb 14, 2006·Journal of Ethnopharmacology·A LibmanD D Soejarto
May 23, 2006·Anti-cancer Agents in Medicinal Chemistry·Rama MukherjeeAnand C Burman
Jun 3, 2006·Natural Product Reports·Petr DzubakJan Sarek
Jul 15, 2006·Journal of Ethnopharmacology·G KumarM Rajasekara Pandian
Nov 2, 2006·Chemical & Pharmaceutical Bulletin·Zong-Tsi ChenChiu-Ming Chen
Dec 26, 2006·Fitoterapia·Sama VenkateshM Ramesh
Mar 21, 2007·Journal of Natural Products·Milan UrbanMarian Hajduch

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Citations

Feb 20, 2013·Journal of Agricultural and Food Chemistry·Christelle M AndreWilliam A Laing
Nov 12, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiang YinDao-Feng Chen
Dec 22, 2009·Natural Product Reports·Joseph D Connolly, Robert A Hill
Apr 14, 2020·Natural Product Research·Pattamaporn WosawatPanawan Moosophon
Dec 11, 2019·Natural Product Research·Luu Hong TruongChau Van Minh
Nov 6, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shuang SunZhenya Zhang
Apr 11, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shuang SunZhenya Zhang

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