Aug 1, 1977

Cytotoxicity and cell cycle specificity of homoharringtonine

Antimicrobial Agents and Chemotherapy
D M Baaske, P Heinstein

Abstract

The plant alkaloid, homoharringtonine, isolated from Cephalotaxus harringtonia is cytotoxic to HeLa, KB, and L cells growing in monolayer cell cultures. This effect appears to be cell-cycle specific. In synchronized KB cells, protein synthesis was preferentially inhibited in the G(1) and G(2) phases (70 and 45% inhibition, respectively) as might be expected for a protein-synthesis inhibitor.

  • References8
  • Citations19
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Mentioned in this Paper

Plant alkaloid
Thymidine
Cell Culture Techniques
Protein Biosynthesis
Cytotoxicity
Staphylococcal Protein A
Cell Division Phases
L Cells (Cell Line)
Cephalotaxus harringtonia
Cell Cycle

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