Cytotoxicity and enhancement activity of essential oil from Zanthoxylum bungeanum Maxim. as a natural transdermal penetration enhancer

Journal of Zhejiang University. Science. B
Yi LanYe-wen Zhang


The aim of this present study is to investigate the effect of Zanthoxylum bungeanum oil (essential oil from Z. bungeanum Maxim.) on cytotoxicity and the transdermal permeation of 5-fluorouracil and indomethacin. The cytotoxicity of Z. bungeanum oil on dermal fibroblasts and epidermal keratinocytes was studied using an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The rat skin was employed to determine the percutaneous penetration enhancement effect of Z. bungeanum oil on hydrophilic and lipophilic model drugs, i.e., 5-fluorouracil and indomethacin. The secondary structure changes of the rat stratum corneum (SC) were determined using attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), and saturated solubilities and SC/vehicle partition coefficients of two model drugs with and without Z. bungeanum oil were also measured to understand its related mechanisms of action. It was found that the half maximal inhibitory concentration (IC50) values of Z. bungeanum oil were significantly lower in HaCaT and CCC-ESF-1 cell lines compared to the well-established and standard penetration enhancer Azone. The Z. bungeanum oil at various concentrations effectively facilitated the percutaneo...Continue Reading


Apr 1, 1984·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·W G ReifenrathW W Jederberg
Feb 21, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amit Kumar JainRamesh Panchagnula
May 7, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·H K VaddiS Y Chan
Sep 16, 2003·International Journal of Pharmaceutics·Victor M MeidanBozena Michniak
Mar 5, 2004·Chemistry and Physics of Lipids·Jarmila ZbytovskáReinhard H H Neubert
Jan 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sunil T K Narishetty, Ramesh Panchagnula
Apr 27, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Chun-feng ZhangHui-nan Zhao
Dec 7, 2007·International Journal of Pharmaceutics·Ligang ZhaoZhonggui He
Dec 7, 2007·Drug Discovery Today·Mohammed AqilAsgar Ali
Mar 14, 2008·International Journal of Pharmaceutics·Wen HeMian Zhang
May 1, 2008·The AAPS Journal·Bharti SapraA K Tiwary
Aug 19, 2009·International Journal of Pharmaceutics·Wen HeMin Feng
Nov 11, 2009·International Journal of Pharmaceutics·Diksha KaushikBozena Michniak-Kohn
Jul 27, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Wensheng XiangXiangjing Wang
Oct 19, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Priya BathejaBozena Michniak-Kohn
Dec 24, 2011·Journal of Ethnopharmacology·Qiao-feng WuChen-huan Yu


Dec 29, 2015·Bioorganic & Medicinal Chemistry Letters·Jun-Mian TianJin-Ming Gao
Apr 5, 2016·Journal of Ethnopharmacology·Keyou LiTiancun Xiao
May 8, 2016·International Journal of Pharmaceutics·Feng XieDong-Hai Zhang
Oct 27, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuan WangJin-Ming Gao
Dec 16, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jun ChenXi-Xiong Yang
Oct 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Aleksandra ShedoevaChen Fan

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