PMID: 11020250Oct 6, 2000

Cytotoxicity and probable mechanism of action of sulphimidazole

The Journal of Antimicrobial Chemotherapy
Mario CastelliG Baggio

Abstract

Sulphimidazole (1-methyl-2((4-aminophenyl)-sulphonyl)-amino-5-nitroimidazole) is a new compound in which a p-aminobenzenesulphonamide radical has been attached at position 2 of the 5-nitroimidazole ring. It possesses a useful spectrum of activity in vitro against various anaerobic microorganisms and its action against aerobic and facultative bacteria is synergically enhanced in association with trimethoprim. In the present study, we determined the cytotoxicity in vitro of sulphimidazole and trimethoprim, both alone and in combination, and analysed the viability of Vero cells and the protein content of their cell lysate in the presence of increasing concentrations of these drugs. Also, in order to verify the hypothesis that the action of sulphimidazole against aerobic and facultative bacteria is mediated by the sulphonamide component of the molecule, while that against anaerobic bacteria depends on the action of the nitro group of the 5-nitroimidazole ring, we studied the mechanism of action of the new compound both indirectly, by means of microbiological techniques, and directly, by determining its oxidoreduction potential with respect to that of metronidazole. The results show that sulphimidazole is only slightly toxic in vitr...Continue Reading

References

Dec 1, 1979·The Journal of Pharmacy and Pharmacology·A V Reynolds
Dec 1, 1977·Journal of Medicinal Chemistry·R C TweitS Ziecina
Jun 1, 1977·British Journal of Cancer·E J HallJ Biaglow
May 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mario CastelliI Galatulas
May 1, 1986·The Journal of Allergy and Clinical Immunology·L M MulfingerR A Wilson
Nov 20, 1980·The New England Journal of Medicine·J Koch-Weser, P Goldman
Nov 1, 1981·British Journal of Cancer·R J KnoxD I Edwards
Mar 1, 1982·International Journal of Radiation Oncology, Biology, Physics·D I EdwardsR C Knight
Aug 1, 1981·The Journal of Antimicrobial Chemotherapy·A V Reynolds
Jan 1, 1993·The Journal of Antimicrobial Chemotherapy·D I Edwards
Jul 1, 1997·The Journal of Antimicrobial Chemotherapy·Mario CastelliS Roffia

Citations

Jul 18, 2002·Journal of Inorganic Biochemistry·Nadeshda Galván-TejadaNoráh Barba-Behrens
Nov 7, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Monica MalagoliMario Castelli
Jan 1, 2008·Acta Crystallographica. Section E, Structure Reports Online·Bo Yang
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Yong-Tao WangGui-Mei Tang
Jan 1, 2008·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Yaseen A Al-SoudChristophe Pannecouque

Related Concepts

1-methyl-2-((4-aminophenyl)sulfonyl)amino-5-nitroimidazole
Antibiotics
Cercopithecus tantalus
Clostridium
Polychemotherapy
Gram-Negative Bacteria
Gram-Positive Bacteria
Nitroimidazoles
Sulfonamides
Trimpex

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.