PMID: 6975632Oct 1, 1981Paper

Cytotoxicity of anti-Fab antibodies against B lymphocytes in rheumatoid arthritis

Arthritis and Rheumatism
H NasuP I Terasaki

Abstract

Anti-Fab antibody titers were positive in 70% of rheumatoid arthritis patients (54 of 77) and 3% (1 of 35) of healthy donors. Their specificity was examined by inhibition of the radioimmunoassay for anti-Fab antibodies, which demonstrated that they are against the Fd region of the intact immunoglobulin molecule. In addition, anti-Fab antibodies have broad specificities for IgG antigens, shown by inhibition with myeloma IgG. They are cytotoxic against B (20% of B cells from most healthy donors) but not T lymphocytes, with cytotoxicity greater at 5 degrees C than 37 degrees C. These studies show that the anti-Fab antibodies interact with allotypic or idiotypic determinants on subpopulations of B lymphocyte cell surface antigens.

References

Feb 1, 1978·American Journal of Clinical Pathology·P I TerasakiY Iwaki
Jul 1, 1979·Tissue Antigens·G Ozturk, P I Terasaki
Jan 1, 1978·Scandinavian Journal of Immunology·G Möller
May 1, 1976·Arthritis and Rheumatism·H A SilvermanJ C McGlamory
Oct 1, 1970·The New England Journal of Medicine·P I TerasakiE V Barnett
Apr 1, 1965·The Journal of Experimental Medicine·M HARBOEK AHO
Aug 1, 1960·Archives of Biochemistry and Biophysics·A NISONOFFD L WOERNLEY

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Citations

Apr 15, 1985·Experientia·T Kouri
Nov 1, 1990·Molecular Immunology·J Simeckova-Rosenberg, L S Rodkey
Dec 1, 1984·Arthritis and Rheumatism·J E PersselinR H Stevens
May 1, 1985·Arthritis and Rheumatism·R HeimerJ L Abruzzo

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