Cytotoxicity of commonly used solvents at elevated temperatures

Journal of Cellular Physiology
G C LiE C Shiu

Abstract

At 43 degrees C (but not at 41 degrees C), organic solvents used to dissolve water-insoluble chemotherapeutic agents become themselves lethal to cells. This finding is not unique to Chinese hamster cells (HA-1); mouse mammary sarcoma cells (EMT-6) behave similarly. The solvent concentrations involved are in the range of those needed to make drug solutions. Hence experiments measuring drug-cell interactions at elevated temperatures must include controls which independently measure solvent effects.

References

Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·G M HahnI Har-Kedar
May 1, 1975·Cancer·S R BraunW Caldwell
Apr 1, 1973·Journal of the National Cancer Institute·H A Johnson, M Pavelec
Apr 1, 1966·Experimental Cell Research·S J YangM A Bagshaw

Citations

Jan 1, 1983·Pharmacology & Therapeutics·H Kalant, A D Lê
Apr 7, 2007·Shock·Hirokazu SasakiShiro Mishima
Apr 13, 2001·Emergency Medicine Journal : EMJ·C J Gordon
Jun 1, 1983·The British Journal of Radiology·J V Moore
Jul 1, 1981·International Journal of Radiation Oncology, Biology, Physics·J T LeithA S Glicksman
May 1, 1984·Alcoholism, Clinical and Experimental Research·L Gailis, A Tourigny
Jun 1, 1984·Journal of Applied Toxicology : JAT·C C Willhite, P I Katz
Dec 1, 1986·Developmental Medicine and Child Neurology·M S SmithJ B Upfold
Mar 15, 1997·Annals of the New York Academy of Sciences·C J Gordon, Y Yang
Apr 10, 2016·Journal of Biomedical Materials Research. Part a·Michael KeeneyFan Yang

Related Concepts

Ethanol
Cell Survival
Rheumabene
Dimethylformamide
Dose-Response Relationship, Drug
Solvents

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.