PMID: 1212351Aug 1, 1975Paper

Cytotoxicity of cyclophosphamide in the rat incisor

British Journal of Cancer
A K Adatia

Abstract

Three of the 4 groups of 3 Wistar rats each were given 40 mg, 80 mg and 120 mg cyclophosphamide/kg respectively by single intraperitoneal injections. The fourth group was given 2 ml of normal saline as control. One animal from each group was killed after 1, 4 and 8 days. The incisor teeth of all experimental animals showed evidence of cytotoxic injury, which appeared to be more severe with increasing dosage, to the undifferentiated mesenchymal cells in the proliferating zone of the pulp close to the basal odontogenic epithelium, cessation of root growth and relative acellularity of the basal area of the pulp. Evidence of cytotoxicity to the odontogenic epithelium was seen only in the groups given 80 mg/kg and 120 mg/kg. Resolution of the cytotoxic injury and re-establishment of normal basal odontogenesis were seen in the 40 mg dose group by the eighth day but appeared to be slower with increasing dosage. It would seem that of the rapidly proliferating epithelial and mesenchymal odontogenic cells in the basal area of the rat incisor those in the mesenchyme may be most susceptible to the cytotoxicity of cyclophosphamide. The odontogenic epithelium may be resistant to the cytotoxicity of 40 mg cyclophosphamide/kg. The results may ...Continue Reading

Citations

Dec 1, 2015·Case Reports in Dentistry·Victor CostaEstela Kaminagakura
Jun 4, 2014·Odontology·Tomomi KawakamiHiroyuki Karibe
Oct 1, 1996·Acta Odontologica Scandinavica·M Näsman, L Hammarström
Apr 1, 1993·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A J MouleK F Adkins
Jan 10, 2004·Toxicologic Pathology·Philip H LongAbraham Nyska
Jan 10, 2014·Archives of Oral Biology·T MitomiS Kinoshita-Kawano

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