Cytotoxicity of half sandwich ruthenium(II) complexes with strong hydrogen bond acceptor ligands and their mechanism of action

Journal of Inorganic Biochemistry
Sangeeta DasAshoka G Samuelson

Abstract

Neutral and cationic organometallic ruthenium(II) piano stool complexes of the type [(eta(6)-cymene)RuCl(X)(Y)] (complexes R1-R8) has been synthesized and characterized. In cationic complexes, X, Y is either a eta(2) phosphorus ligand such as 1,1-bis(diphenylphosphino)methane (DPPM) and 1,2-bis(diphenylphosphino)ethane (DPPE) or partially oxidized ligands such as 1,2-bis(diphenylphosphino)methane monooxide (DPPMO) and 1,2-bis(diphenylphosphino)ethane monooxide (DPPEO) which are strong hydrogen bond acceptors. In neutral complexes, X is chloride and Y is a monodentate phosphorous donor. Complexes with DPPM and DPPMO ligands ([(eta(6)-cymene)Ru(eta(2)-DPPM)Cl]PF(6) (R2), [(eta(6)-cymene)Ru(eta(2)-DPPMO)Cl]PF(6) (R3), [(eta(6)-cymene)Ru(eta(1)-DPPM)Cl(2)] (R5) and [(eta(6)-cymene)Ru(eta(1)-DPPMO)Cl(2)] (R6) show good cytotoxicity. Growth inhibition study of several human cancer cell lines by these complexes has been carried out. Mechanistic studies for R5 and R6 show that inhibition of cancer cell growth involves both cell cycle arrest and apoptosis induction. Using an apoptosis PCR array, we identified the sets of anti-apoptotic genes that were down regulated and pro-apoptotic genes that were up regulated. These complexes were al...Continue Reading

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Citations

May 23, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Lara MassaiLuigi Messori
Apr 26, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Ying FuPeter J Sadler
Mar 7, 2018·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Benelita T ElieMaría Contel
Jan 20, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·A Rodríguez-BárzanoP C McGowan
Feb 16, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Vanesa Fernández-MoreiraM Concepción Gimeno
May 23, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Agnieszka GilewskaEliza Turlej
May 14, 2016·European Journal of Inorganic Chemistry·Yosra BenabdelouahabEva Royo

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