Cytotoxicity of halogenated benzenes and its relationship with logP

Toxicology in Vitro : an International Journal Published in Association with BIBRA
G FratelloA Stammati

Abstract

The in vitro toxicity of a series of environmentally relevant halobenzenes was tested using a Chinese hamster lung fibroblast cell line and its relationship with the logarithm of octanol/water partition coefficient (logP) was investigated. Since we wanted to study the direct biological activity of the parent substances, we have used the V-79 cell line that does not express phase I metabolic activities. Moreover, because of the available knowledge on the substances, we decided to perform the colony-forming ability test (CFA) and to analyse the DNA damage by a cytofluorimetric assay. To identify the concentration range at which the toxic effect could be detected, a prescreen with the neutral red assay has been performed. All the substances tested were positive in the CFA, but, according to the concentration values inhibiting this activity by 50%, they can be divided into two groups of differing toxicity. The FACScan analysis shows for the majority of the halobenzenes a clear hypodiploid peak. A good correlation between values describing the concentration that inhibits CFA by 50% and logP was found, indicating that it depends on the hydrophobic properties of the compounds and that logP is a suitable descriptor.

References

Dec 1, 1994·Human & Experimental Toxicology·C den BestenP J van Bladeren
Sep 1, 1993·Toxicology Letters·K Jansson, V Jansson
Oct 1, 1994·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H SaitoI Tomita
Jan 1, 1987·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H Babich, E Borenfreund

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Citations

Mar 6, 2012·Environmental Toxicology and Pharmacology·Jing GuoZengtian Sun
Jun 24, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yi Yun PangHan Kiat Ho
Dec 19, 2020·ACS Medicinal Chemistry Letters·Maria ChatzopoulouAngela J Russell

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