Cytotoxicity of organic surface coating agents used for nanoparticles synthesis and stability

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Ying ZhangHongtao Yu

Abstract

Impact on health by nanomaterials has become a public concern with the great advances of nanomaterials for various applications. Surface coating agents are an integral part of nanoparticles, but not enough attention has been paid during toxicity tests of nanoparticles. As a result, there are inconsistent toxicity results for certain nanomaterials. In this study, we explored the cytotoxicity of eleven commonly used surface coating agents in two cell lines, human epidermal keratinocyte (HaCaT) and lung fibroblast (CRL-1490) cells, at surface coating agent concentrations of 3, 10, 30, and 100 μM. Two exposure time points, 2 h and 24 h, were employed for the study. Six of the eleven surface coating agents are cytotoxic, especially those surfactants with long aliphatic chains, both cationic (cetyltrimethylammonium bromide, oleylamine, tetraoctylammonium bromide, and hexadecylamine) and anionic (sodium dodecylsulfate). In addition, exposure time and the use of different cell lines also affect the cytotoxicity results. Therefore, factors such as cell lines used and exposure times must be considered when conducting toxicity tests or comparing cytotoxicity results.

References

Jan 1, 1974·Archives of Toxicology·Ch Gloxhuber
Mar 29, 2001·Journal of the American Chemical Society·Z A Peng, X Peng
Dec 29, 2006·Small·Nadine PernodetMiriam Rafailovich
May 24, 2011·Environmental Science & Technology·Clément LevardGordon E Brown
Feb 25, 2010·Chemical Physics Letters·Wentong LuParesh Chandra Ray
Mar 29, 2014·Journal of Food and Drug Analysis·Danielle McShanHongtao Yu

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Citations

Jun 16, 2015·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Ying ZhangHongtao Yu
Jun 21, 2016·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Ying ZhangHongtao Yu
Feb 20, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·B DumontelV Cauda
Aug 8, 2019·Contact Dermatitis·Seungah YooJihyun Lee
Jan 1, 2020·Nanomaterials·Roxana Cristina PopescuBogdan Stefan Vasile
Jan 24, 2019·International Journal of Molecular Sciences·Chengzhu LiaoSie Chin Tjong
Jan 10, 2018·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Hua DengHongtao Yu
Dec 4, 2020·International Journal of Molecular Sciences·Yuchao LiSie Chin Tjong
Mar 30, 2021·ACS Omega·Rufus Mart Ceasar R Ramos, Michelle D Regulacio
Apr 9, 2021·Drug Discovery Today·Ruba IsmailIldikó Csóka
May 21, 2021·Chemistry : a European Journal·Earl Adrian D R Hans, Michelle D Regulacio
Aug 15, 2021·Journal of Biomedical Materials Research. Part a·Emi A KiyotakeMichael S Detamore

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