Cytotoxicity of phenol to musculoskeletal tumours

The Journal of Bone and Joint Surgery. British Volume
U QuintR T Müller

Abstract

Local treatment with phenol is often used after intralesional excision of chondroblastomas and giant-cell tumours which involve bone near joints, and has been shown to reduce the rate of recurrence. The ideal concentration of phenol is uncertain, but may be important because of the high rate of absorption and toxicity. We have studied the effectiveness of different concentrations on standard sarcoma cell lines. Our results suggest that a 5% solution of phenol is effective against dispersed single cells, and that higher concentrations give no significant advantage, but create problems due to lack of homogeneous mixing, temperature and safety.

Citations

Jun 10, 2016·Phytotherapy Research : PTR·Shefton ParkerCharlie Changli Xue
Jan 15, 2009·Clinical Orthopaedics and Related Research·Chad AaronsH Thomas Temple
Sep 8, 2006·Clinical Orthopaedics and Related Research·Valerae O LewisMichael A Simon
Nov 4, 2011·The Journal of Bone and Joint Surgery. American Volume·Robert J SteffnerTerrance D Peabody
Jul 3, 1999·The Journal of Bone and Joint Surgery. American Volume·H R BlackleyR S Bell
Aug 14, 2010·Clinical Orthopaedics and Related Research·Frank M KlenkeFranklin H Sim
May 2, 2014·Journal of Orthopaedic Surgery·Manasseh NithyananthVernon N Lee

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