Cytotoxicity of povidone-iodine on cultured mammalian cells

Nihon Shishubyo Gakkai kaishi
N IwasakiT Tsutsui

Abstract

Cytotoxicity of povidone-iodine on cultured mammalian cells was studied using cultured Chinese hamster lung cells (V 79 cells). Treatment of V 79 cells with povidone-iodine at 100-500 micrograms/ml for 24 to 72 hr induced a growth inhibition of the cells in a dose-dependent manner. Although minimum inhibition of survival of V 79 cells was elicited in cultures treated with povidone-iodine at 100-300 micrograms/ml for 2 to 24 hr, treatment at 500 micrograms/ml for 6 to 24 hr resulted in decrease in cell survival in a treatment time-dependent fasion. Exposure of cells to povidone-iodine at 100-500 micrograms/ml for 2 hr caused inhibition of DNA, RNA or protein synthesis of cells up to 13.9% of untreated cells. These results indicate that cytotoxicity of povidone-iodine occurs in dose- and treatment time-dependent manners and that povidone-iodine induces inhibition of DNA, RNA and protein syntheses of cells, even by the treatment which causes no reduction of cell survival.

Citations

Oct 11, 2011·Journal of Anesthesia·Soon Ho CheongSung Ho Moon
Feb 27, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kayode O OduwoleJames P O'Gara

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Dermatology : International Journal for Clinical and Investigative Dermatology
Hironori MasakiKeizo Matsumoto
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Aaron A GlynnJames P O'Gara
Dermatology : International Journal for Clinical and Investigative Dermatology
Tsuyoshi NagatakeKazunori Oishi
© 2022 Meta ULC. All rights reserved