Cytotoxicity of selected Cameroonian medicinal plants and Nauclea pobeguinii towards multi-factorial drug-resistant cancer cells

BMC Complementary and Alternative Medicine
Victor KueteThomas Efferth

Abstract

Malignacies are still a major public concern worldwide and despite the intensive search for new chemotherapeutic agents, treatment still remains a challenging issue. This work was designed to assess the cytotoxicity of six selected Cameroonian medicinal plants, including Nauclea pobeguinii and its constituents 3-acetoxy-11-oxo-urs-12-ene (1), p-coumaric acid (2), citric acid trimethyl ester (3), resveratrol (4), resveratrol β- D -glucopyranoside (5) and strictosamide (6), against 8 drug-sensitive and multidrug-resistant (MDR) cancer cell lines. The resazurin reduction assay was used to evaluate the cytotoxicity of the crude extracts and compounds, whilst column chromatography was used to isolate the constituents of Nauclea pobeguinii. Structural characterization of isolated compounds was performed using nuclear magnetic resonance (NMR) spectroscopic data. Preliminary experiments on leukemia CCRF-CEM cells at 40 μg/mL showed that the leaves and bark extracts from Tragia benthamii, Canarium schweinfurthii, Myrianthus arboreus, Dischistocalyx grandifolius and Fagara macrophylla induced more than 50 % growth of this cell line contrary to the leaves and bark extracts of N. pobeguinii. IC50 values below or around 30 μg/mL were obtain...Continue Reading

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Citations

Nov 14, 2017·Natural Product Research·Sidjui Sidjui LazareFolefoc Ngosong Gabriel
Jan 11, 2018·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Jean J K BankeuMuhammad S Ali
May 24, 2018·Journal of Complementary & Integrative Medicine·Mbiantcha MariusWego Kamgaing Marius Tresor
May 5, 2020·Angewandte Chemie·Jukiya SakamotoHayato Ishikawa
May 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·José L González-AlfonsoFrancisco J Plou
Nov 16, 2016·Oxidative Medicine and Cellular Longevity·Daniel ZałuskiAnna Bogucka-Kocka
Apr 8, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Timothy OmaraMargaret Chepkemoi Koske

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Methods Mentioned

BETA
column chromatography
NMR
glucosylation

Software Mentioned

Excel

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