Cytotoxicity of silver and copper nanoparticles on rainbow trout (Oncorhynchus mykiss) hepatocytes

Environmental Science and Pollution Research International
Teresa OstaszewskaMaciej Chojnacki

Abstract

Nanoparticles are commonly used in the industry and are present in consumer goods; therefore, evaluation of their potential toxicity is necessary. The aim of the present study was to assess the cytotoxic effects of the nanoparticles of silver (AgNPs) at the concentration of 1.5 mg L-1 and copper (CuNPs) at 0.15 mg L-1 on rainbow trout (Oncorhynchus mykiss) hepatocytes after 28 days of exposure. Histological analysis revealed dilated sinusoids, shrunken hepatocytes, nuclear necrosis, and increased number of Kupffer cells in the liver of fish exposed to nanoparticles. The lowest hepatocyte proliferation index was observed in fish treated with AgNPs. Ultrastructural studies revealed mitochondrial edema and cristolysis, dilated and loosened endoplasmic reticulum, cytoplasm vacuolation, accumulation of lipid droplets, glycogen depletion, and formation of myelin-like bodies. The results also revealed that the liver of fish exposed to copper nanoparticles showed higher regenerative potential indicated by higher proliferation index, more abundant glycogen, and more numerous Kupffer cells compared to the fish treated with silver nanoparticles.

References

Jan 1, 1996·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·T ZahnT Braunbeck
Feb 4, 2006·Science·Andre NelNing Li
Mar 21, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A E M VickersR L Fisher
Sep 19, 2006·FEBS Letters·Nora Anderson, Jürgen Borlak
Feb 9, 2008·Histochemistry and Cell Biology·Tino KurzUlf T Brunk
Apr 15, 2008·Ecotoxicology·Richard D HandyCharles R Tyler
Nov 7, 2008·Analytical and Bioanalytical Chemistry·Marinella FarréDamià Barceló
Feb 24, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Hikaru NishimoriKiyohito Yagi
Feb 25, 2009·ACS Nano·P V AshaRaniSuresh Valiyaveettil
May 19, 2009·Molecular Pharmaceutics·Armen Khatchadourian, Dusica Maysinger
Aug 4, 2010·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Amanda M SchrandAli F Syed
Feb 14, 2012·The Science of the Total Environment·Chia-Pin ChioChung-Min Liao
Oct 23, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Birgit K GaiserVicki Stone
Oct 25, 2012·Journal of Biomedicine & Biotechnology·Byoungcheun LeeJunheon Yoon
Jan 1, 2012·Journal of Environmental Sciences (China)·Rajakumar Govindasamy, Abdul Abdul Rahuman
Mar 26, 2013·The Science of the Total Environment·Dolores FernándezMar Babín
May 27, 2015·International Journal of Environmental Research and Public Health·Mona ConnollyJose M Navas
Sep 19, 2015·Environmental Science and Pollution Research International·Teresa OstaszewskaEwa Sawosz-Chwalibóg
Mar 5, 2016·Ultrastructural Pathology·Mansour AlmansourBashir M Jarrar
Aug 27, 2016·Angewandte Chemie·Lars Michael SkjoldingAnders Baun

❮ Previous
Next ❯

Citations

Apr 17, 2019·International Journal of Molecular Sciences·Aleksandra KalińskaMarcin Gołębiewski
Sep 13, 2019·Current Pharmaceutical Design·Jimena CazenaveAndrea Silvana Rossi
Sep 5, 2020·International Journal of Nanomedicine·Reham Samir HamidaMashael Mohammed Bin-Meferij
Nov 30, 2020·International Journal of Biological Macromolecules·Xinyu SunLi Wang
Jan 16, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fatemeh EzzatkhahHossein Mahmoudvand
Nov 13, 2019·The Science of the Total Environment·Daming WuTing Zhang
May 4, 2020·Environmental Toxicology and Pharmacology·P AthifR K Singhal
Apr 2, 2020·The Science of the Total Environment·Richard ZeumerChristian Schlechtriem
Aug 14, 2020·Environmental Science & Technology·Luqing ZhangWen-Xiong Wang
Jul 10, 2020·Journal of Agricultural and Food Chemistry·Kangjing LiuMingqian Tan

❮ Previous
Next ❯

Methods Mentioned

BETA
transmission electron microscopy
dynamic light-scattering

Software Mentioned

Statistica

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
Andrey MassarskyThomas W Moon
Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
T ZahnT Braunbeck
© 2022 Meta ULC. All rights reserved