PMID: 20650118Aug 1, 1995Paper

Cytotoxicity testing of beta-lactam antibiotics, non-steroidal anti-inflammatory drugs and sulfonamides in primary human keratinocyte cultures

Toxicology in Vitro : an International Journal Published in Association with BIBRA
M Patoux-PibouinA Guillouzo

Abstract

We have studied the cytotoxity to human keratinocytes of three main classes of drugs known to induce cutaneous adverse reactions, namely beta-lactam antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs) and sulfonamides, using the neutral red uptake as an endpoint. IC(50) values were determined for 21 drugs, after 20 hr of exposure and compared with those obtained with rat hepatocytes. NSAIDs were found to be more cytotoxic than beta-lactum antibiotics to human keratinocytes. Large variations in IC(50) values were obtained between molecules of a same class, as well as between keratinocyte cultures from different donors, especially for beta-lactum antibiotics. All NSAIDs and beta-lactam antibiotics tested were more cytotoxic to rat hepatocytes (1.6- to 27-fold). Both cell types were only slightly sensitive to sulfonamides, if at all.

References

Jun 1, 1994·In Vitro Cellular & Developmental Biology. Animal·B HirelA Guillouzo
Jan 1, 1993·Dermatology : International Journal for Clinical and Investigative Dermatology·O CorreiaJ C Roujeau
Feb 1, 1995·Toxicology in Vitro : an International Journal Published in Association with BIBRA·B HirelA Guillouzo
Jan 1, 1993·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A Gueniche, M Ponec

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Citations

Aug 19, 2014·Chemico-biological Interactions·Qin LiuJin-Min Zhao
Jul 1, 2006·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Bo JørgensenFinn Gottrup
Sep 10, 2008·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Hyun-Min HwangJose L Sericano
Dec 17, 2008·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Hyun-Min HwangRobert W Holmes
Feb 9, 2019·Clinical Neuroradiology·C A TaschnerM Prinz
Feb 1, 2017·Molecular Medicine Reports·Li HuangJinmin Zhao

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