d(-) Lactic Acid-Induced Adhesion of Bovine Neutrophils onto Endothelial Cells Is Dependent on Neutrophils Extracellular Traps Formation and CD11b Expression

Frontiers in Immunology
Pablo AlarcónRafael A Burgos

Abstract

Bovine ruminal acidosis is of economic importance as it contributes to reduced milk and meat production. This phenomenon is mainly attributed to an overload of highly fermentable carbohydrate, resulting in increased d(-) lactic acid levels in serum and plasma. Ruminal acidosis correlates with elevated acute phase proteins in blood, along with neutrophil activation and infiltration into various tissues leading to laminitis and aseptic polysynovitis. Previous studies in bovine neutrophils indicated that d(-) lactic acid decreased expression of L-selectin and increased expression of CD11b to concentrations higher than 6 mM, suggesting a potential role in neutrophil adhesion onto endothelia. The two aims of this study were to evaluate whether d(-) lactic acid influenced neutrophil and endothelial adhesion and to trigger neutrophil extracellular trap (NET) production (NETosis) in exposed neutrophils. Exposure of bovine neutrophils to 5 mM d(-) lactic acid elevated NET release compared to unstimulated neutrophil negative controls. Moreover, this NET contains CD11b and histone H4 citrullinated, the latter was dependent on PAD4 activation, a critical enzyme in DNA decondensation and NETosis. Furthermore, NET formation was dependent on ...Continue Reading

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Citations

Oct 17, 2019·Frontiers in Immunology·Sachin Kumar, Madhu Dikshit
Feb 23, 2020·Biology·Ariane NeumannMaren von Köckritz-Blickwede
Nov 19, 2019·Frontiers in Immunology·Naomi-Liza DenningPing Wang
Jul 5, 2019·BMC Veterinary Research·Alejandra Isabel HidalgoRafael A Burgos
May 7, 2020·Frontiers in Veterinary Science·Shuaichen LiJiantao Zhang
Jan 12, 2021·Immune Network·Jae-Han JeonJae Man Lee

Related Concepts

Tissue Adhesions
Blood
Carbohydrates
Cell Adhesion
Plasma Membrane
Fermentation
Histone H4
Inflammation
Meat
Neutrophil

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