d-Amino acids in antimicrobial peptides: a potential approach to treat and combat antimicrobial resistance.

Canadian Journal of Microbiology
Shikha Kapil, Vipasha Sharma

Abstract

Antimicrobial resistance is one of the leading challenges in the human healthcare segment. Advances in antimicrobial resistance have triggered exploration of natural alternatives to stabilize its seriousness. Antimicrobial peptides are small, positively charged oligopeptides that are as potent as commercially available antibiotics against a wide spectrum of organisms, such as Gram-positive bacteria, Gram-negative bacteria, viruses, and fungal strains. In addition to their antibiotic capabilities, these peptides possess anticancer activity, activate the immune response, and regulate inflammation. Peptides have distinct modes of action and fall into various categories due to their amino acid composition. Although antimicrobial peptides specifically target the bacterial cytoplasmic membrane, they can also target the cell nucleus and protein synthesis. Owing to the increasing demand for novel treatments against the threat of antimicrobial resistance, naturally synthesized peptides are a beneficial development concept. Antimicrobial peptides are pervasive and can easily be modified using de-novo synthesis technology. Antimicrobial peptides can be isolated from natural resources such as humans, plants, bacteria, and fungi. This revie...Continue Reading

References

Feb 1, 1977·Quarterly Reviews of Biophysics·G Ehrenstein, H Lecar
Aug 1, 1979·Chemical & Pharmaceutical Bulletin·Y HiraiC Kitada
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D WadeR B Merrifield
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R A CrucianiO Colamonici
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M Zasloff
Apr 1, 1970·Journal of Bacteriology·S C Rittenberg, M Shilo
Apr 1, 1969·Journal of Bacteriology·W S Champney, R A Jensen
Oct 1, 1970·Journal of Bacteriology·W S Champney, R A Jensen
Oct 1, 1982·European Journal of Biochemistry·R Hakenbeck, M Kohiyama
Sep 1, 1994·Protein Science : a Publication of the Protein Society·William C WimleyS H White
Mar 1, 1995·Journal of Bacteriology·I C Sutcliffe, R R Russell
May 1, 1993·Molecular & General Genetics : MGG·L Selakovitch-ChenuA M Sicard
Mar 1, 1996·European Journal of Biochemistry·H Kleinkauf, H Von Döhren
Feb 23, 1996·The Journal of Biological Chemistry·E B MallowC L Bevins
Mar 29, 1996·The Journal of Biological Chemistry·Yechiel Shai, Z Oren
May 1, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M Sela, E Zisman
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·J P BriandS Muller
Jul 24, 1998·Biophysical Journal·L YangH W Huang
Jan 29, 1999·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·P M Hwang, Hans J Vogel
Jun 6, 2000·Advanced Drug Delivery Reviews·E AllémannR Gurny
Jul 6, 2000·Immunopharmacology·S Matsuda, S Koyasu
Jul 27, 2001·Nature·S Fernandez-LopezM Reza Ghadiri
Aug 18, 2001·Biophysical Journal·L YangH W Huang
Feb 20, 2002·Biologicals : Journal of the International Association of Biological Standardization·Ferenc Hudecz
Mar 5, 2003·Pharmacological Reviews·Michael R Yeaman, Nannette Y Yount
Oct 7, 2003·Annual Review of Microbiology·John E Cronan
Dec 19, 2003·Nucleic Acids Research·Zhe Wang, Guangshun Wang
Jan 1, 1951·Cold Spring Harbor Symposia on Quantitative Biology·R D HOTCHKISS
Jun 4, 2004·The Journal of Peptide Research : Official Journal of the American Peptide Society·S M OwenR B Lal
Jul 1, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert D ArbeitDaptomycin 98-01 and 99-01 Investigators
Jul 21, 2004·Nature Reviews. Microbiology·R Elizabeth Sockett, Carey Lambert
Nov 16, 2004·International Journal of Pharmaceutics·Stefano SalmasoPaolo Caliceti
Nov 24, 2004·International Journal of Antimicrobial Agents·K V R ReddyC Aranha
Nov 24, 2004·Infection and Immunity·Miguel A CamposJose A Bengoechea
Jan 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Regina TugyiFerenc Hudecz
Jan 11, 2005·Current Protein & Peptide Science·Dawn M E BowdishRobert E W Hancock
Jan 11, 2005·Protein and Peptide Letters·Sarah R DennisonDavid A Phoenix
Jan 11, 2005·Trends in Microbiology·Steven S BrandaRoberto Kolter
Jul 5, 2005·Bioorganic & Medicinal Chemistry·W Seth HorneGlen R Nemerow
Oct 20, 2005·Journal of Bioscience and Bioengineering·Y Asano, T L Lübbehüsen
Dec 13, 2005·Microbiology and Molecular Biology Reviews : MMBR·Dirk-Jan Scheffers, Mariana G Pinho
May 20, 2006·Cellular and Molecular Life Sciences : CMLS·M PazgierJ Lubkowski
Jul 19, 2006·Clinical Microbiology Reviews·Håvard JenssenRobert E W Hancock
Sep 9, 2006·Microbiology and Molecular Biology Reviews : MMBR·Kevin D Young
Oct 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Arik MakovitzkiYechiel Shai
Dec 6, 2006·Antimicrobial Agents and Chemotherapy·Zhigang LiuNeville R Kallenbach
Dec 13, 2006·Antimicrobial Agents and Chemotherapy·Yuxin ChenRobert S Hodges
Dec 16, 2006·ACS Chemical Biology·Wilfred A van der Donk
Mar 8, 2007·Bioinformatics·Christopher D FjellArtem Cherkasov
Mar 27, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jianxu LiWeimin Gong
Jul 5, 2007·Nature Reviews. Molecular Cell Biology·Satyajit Mayor, Richard E Pagano
Jul 12, 2007·Seminars in Immunopathology·Katherine Radek, Richard L Gallo
Sep 7, 2007·Microbiology and Molecular Biology Reviews : MMBR·Marcus Miethke, Mohamed A Marahiel
Dec 12, 2007·FEMS Microbiology Reviews·Waldemar Vollmer
Jan 16, 2008·FEMS Microbiology Reviews·Waldemar VollmerMiguel A de Pedro
Feb 12, 2008·Nature Reviews. Microbiology·Yong-Mei Zhang, Charles O Rock
Mar 28, 2008·Biotechnology and Bioengineering·James D Bryers
Jul 8, 2008·Biochimica Et Biophysica Acta·Durba SenguptaSiewert-Jan Marrink
Sep 11, 2008·The Journal of Biological Chemistry·Aisling S DuganWalter J Atwood
Nov 26, 2008·Biochimica Et Biophysica Acta·Shahar Rotem, Amram Mor
Dec 3, 2008·Microbiology·Enrique LlobetJose A Bengoechea
May 28, 2009·Antimicrobial Agents and Chemotherapy·Fuminori YoneyamaKenji Sonomoto
Jun 6, 2009·Future Microbiology·Giovanna RiccardiSilvia Buroni
Jun 10, 2009·Journal of Peptide Science : an Official Publication of the European Peptide Society·Alfonso Enrique Islas-RodrìguezMaria Luisa Mangoni
Sep 19, 2009·Science·Hubert LamMatthew K Waldor
Sep 21, 2010·International Journal of Hygiene and Environmental Health·Natalia Y Markelova
Feb 9, 2011·Antimicrobial Agents and Chemotherapy·Marisa Ann AzadCynthia Ross Friedman
May 12, 2011·Nucleic Acids Research·Marc RöttigOliver Kohlbacher
May 12, 2011·Cellular and Molecular Life Sciences : CMLS·J Michael Conlon
Jun 18, 2011·Trends in Biotechnology·Leonard T NguyenHans J Vogel
Nov 3, 2011·Frontiers in Microbiology·Angela H A M van HoekHenk J M Aarts
Jan 17, 2012·Progress in Lipid Research·Vitor TeixeiraMargarida Bastos
Jan 27, 2012·Biology Letters·Michelle G J L Habets, Michael A Brockhurst
Feb 9, 2012·Antimicrobial Agents and Chemotherapy·S NambiarE M Cox
Mar 28, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·George G ZhanelJames A Karlowsky
Jun 27, 2012·The Journal of Biological Chemistry·Lusine H DemirkhanyanGregory B Melikyan
Aug 29, 2012·Antimicrobial Agents and Chemotherapy·Jongkon SaisingFriedrich Götz
Nov 2, 2012·Antimicrobial Agents and Chemotherapy·Nicole BertholdRalf Hoffmann
Feb 14, 2013·Antimicrobial Agents and Chemotherapy·Song Lin ChuaMichael Givskov
Apr 27, 2013·Pathogens and Disease·Shaan L Gellatly, Robert E W Hancock
Nov 7, 2013·ACS Chemical Biology·Marianna IorioStefano Donadio
Nov 30, 2013·Pharmaceuticals·Ali Adem Bahar, Dacheng Ren
Feb 21, 2014·Journal of Indian Society of Periodontology·K HariniShruthi Hegde
Jul 30, 2014·Microbiology·Heramb M Kulkarni, Medicharla V Jagannadham
Dec 2, 2014·Molecular Medicine Reports·Hong DingYali Han
Jan 7, 2015·Nature·Losee L LingKim Lewis
Apr 22, 2015·Antimicrobial Agents and Chemotherapy·Kasper L JønssonMartin R Jakobsen
May 12, 2015·Peptides·Maria Luisa MangoniAlison M McDermott
Jan 15, 2016·Current Biology : CB·Ling-Juan Zhang, Richard L Gallo
Feb 24, 2016·Biochimica Et Biophysica Acta·Lucia BiasuttoMario Zoratti
Mar 5, 2016·Current Topics in Microbiology and Immunology·Sabrina Mühlen, Petra Dersch
Mar 24, 2016·Angewandte Chemie·Mathieu F ChellatRainer Riedl
Jun 23, 2016·Biochimie·Marina RautenbachMargitta E Dathe
Jul 18, 2016·Biochimica Et Biophysica Acta·Luz N IrazazabalOctavio L Franco
Oct 1, 2016·Proceedings of the National Academy of Sciences of the United States of America·Stephen A CochraneJohn C Vederas
Mar 3, 2017·Biochimie·Sarah R DennisonDavid A Phoenix
Apr 15, 2017·World Journal of Microbiology & Biotechnology·D XuT Gu
Jul 20, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Bingyun Li, Thomas J Webster
Sep 24, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Seema Patel, Nadeem Akhtar
Oct 6, 2017·Acta Biochimica Et Biophysica Sinica·Fengjing JiaRui Wang
Nov 6, 2017·Probiotics and Antimicrobial Proteins·Kimberly D Saint JeanGregory A Caputo
Nov 11, 2017·Scientific Reports·Abdurraouf ZaetCéline Marban
Jan 27, 2018·PLoS Computational Biology·Guillaume MarçaisAleksey Zimin
Feb 28, 2018·Nature Chemical Biology·Yong-Xin LiPei-Yuan Qian
May 2, 2018·Pharmaceutics·Tomasz M Karpiński, Artur Adamczak
May 17, 2018·Nature Communications·Mazhar Adli
Jun 6, 2018·Frontiers in Microbiology·Lubhandwa S BiswaroOctavio L Franco
Jun 26, 2018·Annals of Agricultural and Environmental Medicine : AAEM·Tomasz MirskiAleksander Michalski
Jul 12, 2018·Proteomics. Clinical Applications·Mayank SaraswatSuvi Renkonen
Aug 25, 2018·Asian Pacific Journal of Cancer Prevention : APJCP·Nahid ZainodiniMohammad Reza Mirzaei
Sep 14, 2018·Nature·Peter A SmithChristopher E Heise
Jan 23, 2019·The Science of the Total Environment·K RafińskaB Buszewski
Mar 1, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Tariq AlamMohammad Ali
Mar 12, 2019·Metal Ions in Life Sciences·Elzbieta Gumienna-Kontecka, Peggy L Carver

Related Concepts

Computational Prediction of Drug-Target Interactions
Amino Acids
Microbicides
Plasma Membrane
Cell Nucleus
Antibiotic Resistance, Microbial
Molecular Stereochemistry
Protein Biosynthesis
Pore Forming Cytotoxic Proteins
Antibiotics

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