d-Amphetamine attenuates decreased cerebral glucose utilization after unilateral sensorimotor cortex contusion in rats

Brain Research
S A QueenD M Feeney

Abstract

Unilateral contusion injury to the sensorimotor cortex causes, among other symptoms, a transient contralateral hindlimb hemiparesis in rats. A single i.p. 2 mg/kg dose of d-amphetamine (d-AMPH) 24 h after injury accelerates spontaneous recovery from this particular deficit. The mechanism(s) of spontaneous and d-AMPH enhanced recovery are unknown but alleviation of a neuronal depression has been proposed. This quantitative CMRglu study was designed to determine effects of cortical contusion injury and d-AMPH on CMRglu in cortical and subcortical structures. At 2 days after injury, CMRglu was significantly reduced compared to sham-operated controls only in structures ipsilateral to contusion. Affected structures included the caudate putamen, medial geniculate nucleus, lateral geniculate nucleus and the parietal cortex immediately posterior to injury. By 6 days post-contusion, the hypometabolism partially reversed in all structures. A single low dose of d-AMPH significantly alleviated the post-traumatic CMRglu reduction at 2 days after injury. Importantly, while this alleviation was not significant for any single structure, the main effect of treatment was highly significant. d-AMPH increased CMRglu at 2 days post-injury by 18-33%...Continue Reading

References

Mar 1, 1979·Stroke; a Journal of Cerebral Circulation·K KogureR Busto
Jan 1, 1979·Journal of Neurochemistry·L R WechslerL Sokoloff
Jan 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T KawamataD P Becker
Sep 1, 1991·Neurochemical Research·H M Pappius
Jan 1, 1990·Annual Review of Neuroscience·D W Choi, S M Rothman
Jan 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R Rischke, J Krieglstein
Jul 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I Yamakami, T K McIntosh
Sep 1, 1990·Trends in Pharmacological Sciences·B Meldrum, J Garthwaite
Jan 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W D HeissM Neveling
Mar 1, 1990·Pharmacology, Biochemistry, and Behavior·M G Boyeson, D M Feeney
Jul 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T BeckA Schleicher
Sep 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P NilssonU Ungerstedt
Sep 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G MiesK A Hossmann
Dec 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K ShiraishiR P Simon
Dec 1, 1988·Annals of Neurology·I ShimoyamaJ B Penney
Jan 1, 1988·Journal of Neurosurgery·F L ContrerasH M Eisenberg
Feb 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M NedergaardN H Diemer
Sep 1, 1986·Stroke; a Journal of Cerebral Circulation·D M Feeney, J C Baron
Apr 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W D DietrichB D Watson
Nov 1, 1984·Experimental Neurology·R M Cooper, G A Thurlow
Jun 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F OrziL Sokoloff
Dec 1, 1995·Stroke; a Journal of Cerebral Circulation·D Walker-BatsonR Greenlee
May 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H YaoR Busto

❮ Previous
Next ❯

Citations

Jul 26, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ulf ZiemannLeonardo G Cohen
Aug 25, 2006·Journal of Neurotrauma·Theresa D Hernández
Oct 3, 2012·Journal of Neurotrauma·Mayumi L PrinsDavid A Hovda
Feb 13, 2004·Drugs & Aging·Louise Martinsson, Staffan Eksborg
Aug 20, 2003·QJM : Monthly Journal of the Association of Physicians·D Long, J Young
May 11, 1999·Brain Research. Brain Research Protocols·C GasparovicD M Feeney
Mar 27, 2012·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Amy K Wagner, Kevin T Zitelli
Sep 7, 2011·Pharmacology & Therapeutics·James A Young
Jul 8, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Alexandra N GarciaAnthony E Kline
Dec 30, 2015·Brain Research·Nicole D Osier, C Edward Dixon
Jul 16, 2011·Neurological Research·Rune Skovgaard RasmussenFlemming Fryd Johansen
Mar 29, 2001·The Journal of Head Trauma Rehabilitation·W M BrooksC Gasparovic
Nov 18, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Mayumi L Prins
Oct 9, 2004·Neurorehabilitation and Neural Repair·I MiyaiJ Kang
Jul 24, 2018·Frontiers in Synaptic Neuroscience·Annette Gower, Mario Tiberi

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