d-Amphetamine: disruptive effects on the long-term store of memory and proactive facilitatory effects on learning in inbred mice.

Pharmacology, Biochemistry, and Behavior
J C Crabbe, H P Alpern

Abstract

Male, C57BL/6J mice were given two daily trials on an appetitively-motivated successive brightness discrimination maze problem; they then received daily intraperitoneal injections of saline or d-amphetamine for 5 days. When trained again in the maze, mice in all d-amphetamine groups tended to display impaired retention: retention was significantly impaired in the 2.0 mg/kg group. Naive mice were treated exactly as were the pretrained mice except that they received no initial maze training prior to drug treatments. Mice in all naive d-amphetamine groups tended to display enhanced acquisition of the maze problem: acquisition was significantly enhanced in the 1.0 mg/kg groups. These results could not be explained as effects of d-amphetamine on attentional, motivational or other performance factors.

References

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Sep 16, 1966·Science·J L McGaugh

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Citations

Feb 1, 1978·Behavioral Biology·H P Alpern, S J Jackson

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