D-Amphetamine stimulates D2 dopamine receptor-mediated brain signaling involving arachidonic acid in unanesthetized rats

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Abesh Kumar BhattacharjeeS I Rapoport

Abstract

In rat brain, dopaminergic D(2)-like but not D(1)-like receptors can be coupled to phospholipase A(2) (PLA(2)) activation, to release the second messenger, arachidonic acid (AA, 20:4n-6), from membrane phospholipids. In this study, we hypothesized that D-amphetamine, a dopamine-releasing agent, could initiate such AA signaling. The incorporation coefficient, k* (brain radioactivity/integrated plasma radioactivity) for AA, a marker of the signal, was determined in 62 brain regions of unanesthetized rats that were administered i.p. saline, D-amphetamine (2.5 or 0.5 mg/kg i.p.), or the D(2)-like receptor antagonist raclopride (6 mg/kg, i.v.) before saline or 2.5 mg/kg D-amphetamine. After injecting [1-(14)C]AA intravenously, k* was measured by quantitative autoradiography. Compared to saline-treated controls, D-amphetamine 2.5 mg/kg i.p. increased k* significantly in 27 brain areas rich in D(2)-like receptors. Significant increases were evident in neocortical, extrapyramidal, and limbic regions. Pretreatment with raclopride blocked the increments, but raclopride alone did not alter baseline values of k*. In independent experiments, D-amphetamine 0.5 mg/kg i.p. increased k* significantly in only seven regions, including the nucleus...Continue Reading

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Citations

Feb 16, 2008·Psychopharmacology·Abesh Kumar BhattacharjeeStanley I Rapoport
Dec 10, 2009·Neurochemical Research·Ho-Joo LeeAbesh Kumar Bhattacharjee
Nov 19, 2014·The International Journal of Neuroscience·Ai-Guo SunChao-Hua Cong
Mar 2, 2012·The International Journal of Neuroscience·Epolia RamadanMireille Basselin
Oct 9, 2012·Expert Review of Neurotherapeutics·Robert K McNamara, Francis E Lotrich
Dec 15, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Madhav ThambisettyStanley I Rapoport
Jun 27, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Richard P BazinetHo-Joo Lee
Jun 24, 2008·The International Journal of Neuropsychopharmacology·Abesh K BhattacharjeeStanley I Rapoport
Sep 24, 2011·The International Journal of Neuropsychopharmacology·Hua TanJun-Feng Wang
Jan 8, 2011·Neurochemistry International·Ivan SkelinMirko Diksic
Jul 7, 2015·PloS One·Mandy L Roberts-Crowley, Ann R Rittenhouse
Nov 8, 2020·Neurochemistry International·Kathryn D FischerPaul A Rosenberg

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