D-chiro-inositol glycan reduces food intake by regulating hypothalamic neuropeptide expression via AKT-FoxO1 pathway

Biochemical and Biophysical Research Communications
Yoonjeong JeonEun-Kyoung Kim

Abstract

The regulation of food intake is important for body energy homeostasis. Hypothalamic insulin signaling decreases food intake by upregulating the expression of anorexigenic neuropeptides and downregulating the expression of orexigenic neuropeptides. INS-2, a Mn(2+) chelate of 4-O-(2-amino-2-deoxy-β-D-galactopyranosyl)-3-O-methyl-D-chiro-inositol, acts as an insulin mimetic and sensitizer. We found that intracerebroventricular injection of INS-2 decreased body weight and food intake in mice. In hypothalamic neuronal cell lines, INS-2 downregulated the expression of neuropeptide Y (NPY), an orexigenic neuropeptide, but upregulated the expression of proopiomelanocortin (POMC), an anorexigenic neuropeptide, via modulation of the AKT-forkhead box-containing protein-O1 (FoxO1) pathway. Pretreatment of these cells with INS-2 enhanced the action of insulin on downstream signaling, leading to a further decrease in NPY expression and increase in POMC expression. These data indicate that INS-2 reduces food intake by regulating the expression of the hypothalamic neuropeptide genes through the AKT-FoxO1 pathway downstream of insulin.

References

Jun 1, 1992·Endocrinology·M W SchwartzD P Figlewicz
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·W H BiggsK C Arden
Dec 6, 2003·Science·Morris F White
May 13, 2006·Science·Daniela CotaRandy J Seeley
Jul 11, 2006·The Journal of Clinical Investigation·Leona PlumJens C Brüning
Feb 24, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·E T Rolls
Mar 22, 2012·The American Journal of Clinical Nutrition·Kevin D HallJohn R Speakman
Mar 22, 2013·The Journal of Biological Chemistry·Joseph Larner
Feb 18, 2014·Molecular and Cellular Endocrinology·Roman LazarenkoChien Li

❮ Previous
Next ❯

Citations

Jan 17, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Felicitas Lopez-VicchiDamasia Becu-Villalobos
Dec 6, 2018·Nutrients·Agnieszka Owczarczyk-SaczonekBogusław Buszewski
Jul 17, 2020·Journal of Traditional and Complementary Medicine·M CaputoF Prodam
Jun 3, 2021·International Journal of Molecular Sciences·Arturo BevilacquaCarla Tatone
Jul 28, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·InHyeok ChungMin-Jeong Shin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.