D-cycloserine augmentation of behavioral therapy for the treatment of anxiety disorders: a meta-analysis.

The Journal of Clinical Psychiatry
Allyson BontempoMichael H Bloch

Abstract

To determine the efficacy of D-cycloserine augmentation of behavioral therapy for the treatment of anxiety disorders. Using the search terms D-cycloserine AND anxiety disorders (MeSH), PubMed (1965-June 2011), PsycINFO, and Scopus were searched for randomized, double-blind, placebo-controlled trials of D-cycloserine augmentation of behavioral therapy for the treatment of anxiety disorders. Anxiety disorders were defined as any disorder categorized as such in DSM-IV-TR. A random-effects model was used to calculate the standardized mean difference of change in anxiety rating scale scores with D-cycloserine augmentation compared to placebo, which was the primary outcome measure. Subgroup analysis and meta-regression were used to examine the effects of D-cycloserine dosage and timing (relative to exposure therapy), diagnostic indication, number of therapy sessions, and trial methodological quality on D-cycloserine efficacy. Meta-analysis of 9 trials involving 273 subjects demonstrated a significant benefit from D-cycloserine augmentation (standardized mean difference = 0.46 [95% CI, 0.15 to 0.77], z = 2.89, P = .004). There was no evidence of publication bias, but a moderate, nonsignificant degree of heterogeneity between trials (I...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Mar 9, 2007·Clinical Psychology Review·Bunmi O OlatunjiDavid F Tolin
Apr 20, 2007·The Cochrane Database of Systematic Reviews·S HopewellJ Tierney
May 24, 2007·International Clinical Psychopharmacology·Eric A StorchWayne K Goodman
Jun 26, 2007·Biological Psychiatry·Matt G KushnerEdna B Foa
Feb 5, 2008·The American Journal of Psychiatry·Sabine WilhelmScott L Rauch
Mar 4, 2008·Biological Psychiatry·Melissa M NorbergDavid F Tolin

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Citations

Nov 5, 2013·Journal of Psychiatric Research·Rianne A de KleineAgnes van Minnen
Jan 29, 2013·Nature Neuroscience·Ryan G Parsons, Kerry J Ressler
Oct 23, 2013·European Journal of Psychotraumatology·Rianne A de KleineAgnes van Minnen
Feb 26, 2014·Academic Psychiatry : the Journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry·Mayada Akil, Amit Etkin
Sep 14, 2014·European Archives of Psychiatry and Clinical Neuroscience·Martin WalterLiliana Ramona Demenescu
Dec 25, 2012·Trends in Neurosciences·Andrew Holmes, Nicolas Singewald
Aug 11, 2012·Biological Psychiatry·Mao HorioKenji Hashimoto
Jan 1, 2014·International Journal of Methods in Psychiatric Research·Paul M G EmmelkampBram Vervliet
Nov 14, 2015·Annual Review of Clinical Psychology·Edna B Foa, Carmen P McLean
Sep 14, 2015·The International Journal of Neuropsychopharmacology·Sebastian Schade, Walter Paulus
Feb 14, 2013·Current Opinion in Neurobiology·Brian G DiasKerry J Ressler
Jun 3, 2015·Biology of Mood & Anxiety Disorders·Edward F Pace-SchottMohammed R Milad
Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Kathryn D BakerRick Richardson
Jul 21, 2016·Journal of Psychopharmacology·Jan GünthnerAndrea Reinecke
May 11, 2015·The Cochrane Database of Systematic Reviews·Rasmita OriDan J Stein
Nov 21, 2013·Depression and Anxiety·Filomene G Morrison, Kerry J Ressler
Aug 14, 2018·Current Neuropharmacology·Antonio Del CasaleMaurizio Pompili
Jun 7, 2019·Neurology·Benedetta DemartiniAlberto Priori
Nov 13, 2016·European Psychiatry : the Journal of the Association of European Psychiatrists·A S de LeeuwH G M Westenberg
Sep 6, 2012·Depression and Anxiety·Michelle G Craske
Jun 29, 2014·Expert Review of Neurotherapeutics·Joseph F McGuireEric A Storch
Feb 16, 2018·Journal of Psychopharmacology·Marcella L WoudAndrea Reinecke
Mar 28, 2018·Behavioural Brain Research·Sophie A GeorgeIsrael Liberzon

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