PMID: 9438524Jan 23, 1998Paper

D-cycloserine blocks the effects of ethanol and HA-966 in rats tested in the elevated plus-maze

Alcoholism, Clinical and Experimental Research
V M Moraes Ferreira, G S Morato

Abstract

Previous studies from our laboratory have shown gender-related behavior in rats tested in the elevated plus-maze under the influence of ethanol and other drugs. The present study investigated the effects of pretreatment with the NMDA-receptor partial agonist at the glycine site D-cycloserine (DCS; doses 3 to 9 mg/kg for females; 3 to 12 mg/kg for males, intraperitoneally) on the effects of ethanol (1.2 g/kg, i.p.; 14% w/v) and (+/-)-3-amino-1-hydroxy-2-pyrrolidone (HA-966; 2 or 4 mg/kg, i.p.), an antagonist at the glycine site of the NMDA receptor complex in rats submitted to the elevated plus-maze test. The results showed that DCS, at doses that did not affect the behavior of control animals, significantly (p < 0.05) prevented the increase in the percentage of open-arm entries and the time spent in the open arms of elevated plus-maze test induced by ethanol, exhibiting a U-shaped dose-response curve. Similarly, DCS blocked the anxiolytic effects of HA-966 in animals of both gender. Data confirm our previous results, suggesting that the NMDA-receptor system contributes significantly to the anxiolytic effect of ethanol. Furthermore, the similarity between the blockade by DCS of anxiolysis induced either by ethanol or by HA-966 s...Continue Reading

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Citations

Sep 3, 2013·Psychopharmacology·Andrew HolmesJohn H Krystal
Jul 19, 2000·Pharmacology, Biochemistry, and Behavior·V M FerreiraG S Morato
Jan 22, 2002·Neuroscience and Biobehavioral Reviews·A P CarobrezF G Graeff
Aug 21, 2003·Progress in Neurobiology·Mark J Millan
Dec 23, 2008·Neurotoxicology·Cristiane do Socorro Ferraz MaiaVania Maria Moraes Ferreira
Jun 15, 2007·Pharmacology, Biochemistry, and Behavior·Melissa NunninkThomas A Houpt
Sep 1, 2012·Alcoholism, Clinical and Experimental Research·Lauren DebrouseAndrew Holmes
May 3, 2005·Brain Research·Ying-Jui HoYuan-Feen Tsai
Mar 25, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Taban SeifF Woodward Hopf
Jan 12, 2000·Alcoholism, Clinical and Experimental Research·V M FerreiraG S Morato
Jul 11, 2008·Critical Reviews in Toxicology·Edward J Calabrese

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