D-cycloserine causes transient enhancement of memory for a weak aversive stimulus in day-old chicks (Gallus domesticus)

Neurobiology of Learning and Memory
Robert J. SteeleM G Stewart

Abstract

The N-methyl-D-aspartate (NMDA) receptor plays an important role in acquisition of memory after one-trial passive avoidance training in day-old chicks. Here, we examined the effect of D-cycloserine, a partial agonist of the glycine site on the NMDA receptor, on memory retention after training on weak aversive stimuli (10% methyl anthranilate). Bilateral, or unilateral, intracranial injections of 5 microliters of 600 mumol.l-1 D-cycloserine (DCS) were made into the intermediate and medial hyperstriatum ventrale 5 min posttraining and chicks were tested either 30 min or 1, 6, or 24 h later. Enhanced memory retention (number of chicks avoiding) occurred after bilateral, or left hemisphere, injections of DCS (compared to saline-injected controls), when chicks were tested at 1 and 6 h, but not at 30 min or 24 h posttraining. These data suggest that activation of the glycine site on the NMDA receptor in the immediate posttraining period can transiently extend the retention period of memory for a weak aversive stimulus.

Citations

Apr 24, 2003·Behavioral Neuroscience·Lana LedgerwoodJacquelyn Cranney
Aug 13, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael J Schell
Feb 22, 2012·Journal of Psychopharmacology·Floris KlumpersJohanna M P Baas
Dec 3, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Salim Yalcin InanAyse Saide Sahin
Aug 10, 2021·Frontiers in Genetics·Gabriela Elis WachholzLucas Rosa Fraga

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