d-Cycloserine enhances implicit memory in Alzheimer patients

Neurology
B L SchwartzS I Deutsch

Abstract

We tested the ability of d-cycloserine, a partial glycine agonist acting at the N-methyl-D-aspartate (NMDA) receptor complex, to improve implicit memory in Alzheimer patients in a parallel-group, placebo-controlled, double-blind study. One-hundred eight patients with probable Alzheimer's disease of mild to moderate severity received d-cycloserine (5, 15, or 50 mg) or placebo twice daily for 10 weeks. We then evaluated their ability to identify perceptually degraded words, some of which were repeated over multiple trials across 3 days. Implicit memory performance of words repeated across trials was significantly enhanced for the patients who received 15 mg d-cycloserine compared with those who received placebo. These findings support development of NMDA receptor-mediated glutamatergic interventions for the treatment of Alzheimer-related memory disorders.

Citations

Aug 14, 2003·Current Neurology and Neuroscience Reports·P Murali Doraiswamy
Apr 12, 2005·Neurobiology of Learning and Memory·A Sophie ParnasRick Richardson
Feb 24, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Michael DavisKerry J Ressler
Jan 31, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kenji HashimotoMasaomi Iyo
Jan 22, 2002·Neuroscience and Biobehavioral Reviews·A P CarobrezF G Graeff
Mar 17, 1997·Brain Research. Developmental Brain Research·K WangenF Fonnum
Mar 20, 2003·Behavioural Brain Research·Gernot RiedelJacques Micheau
Aug 23, 2003·European Journal of Medicinal Chemistry·Michaela Jansen, Gerd Dannhardt
Nov 26, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·J L Giacchino, S J Henriksen
Aug 28, 1999·Progress in Neurobiology·T Yamakura, K Shimoji
Feb 7, 1998·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·T PuumalaJ Sirviö
Jul 10, 2003·Lancet Neurology·Rafael RoeslerNadja Schröder
May 24, 2007·International Clinical Psychopharmacology·Eric A StorchWayne K Goodman
Nov 2, 2004·Biological & Pharmaceutical Bulletin·Toshio NarahashiJay Zeus Yeh
Jun 28, 2003·CNS Drugs·D Allan Butterfield, Chava B Pocernich
May 15, 2007·Psychopharmacology·Armin ZlomuzicaEkrem Dere
Jul 19, 2008·Lancet Neurology·Lorraine V KaliaMichael W Salter
Dec 10, 1999·Journal of Clinical Psychopharmacology·S E FileC Fernandes
Nov 19, 2003·Journal of Clinical Psychopharmacology·Rafael RoeslerNadja Schröder
Sep 16, 2005·Expert Review of Neurotherapeutics·Nicholas A Clarke, Paul T Francis
Oct 2, 2003·Expert Opinion on Investigational Drugs·Steven K Baker, Mark A Tarnopolsky
Apr 3, 2001·Expert Opinion on Investigational Drugs·M Emre, N Qizilbash
May 25, 2004·Expert Opinion on Investigational Drugs·Cyrille Sur, Gene G Kinney
Jan 18, 2011·Pharmacology, Biochemistry, and Behavior·Rafael Roesler, Nadja Schröder
Feb 17, 2010·Neuropharmacology·Paul T FrancisMitchell K Lai
Oct 1, 2013·Pharmacology Research & Perspectives·Seth C HopkinsThomas H Large
Aug 22, 2006·Biological Psychiatry·Michael DavisRick Richardson
Nov 6, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Halina Baran, Berthold Kepplinger
Sep 14, 2015·The International Journal of Neuropsychopharmacology·Sebastian Schade, Walter Paulus
Apr 7, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Se Jin ParkJong Hoon Ryu
Jul 31, 2007·Behaviour Research and Therapy·Stefan G Hofmann
Apr 16, 2009·The International Journal of Neuropsychopharmacology·Uriel Heresco-LevyIlana Kremer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.