D-dimer and international normalized ratio (INR) are correlated with tumor markers and disease stage in colorectal cancer patients

Cancer Biomarkers : Section a of Disease Markers
Leyla KilicFaruk Tas

Abstract

The aim of this study is to evaluate the correlation of coagulation tests with various clinicopathological variables and tumor markers among colorectal cancer (CRC) patients. Ninety-four CRC patients were included for evaluation of clinicopathological factors, coagulation assays and tumor marker levels. Metastatic disease was related with elevated INR (p= 0.03). Stage III patients had higher D-dimer values compared with stage II patients (p= 0.03). Correlation of tumor markers indicated a tendency towards elevated D-dimer levels for CEA values higher than median (p= 0.01). High CA 19-9 levels were also associated with higher INR (p= 0.007). Elderly age, distant metastasis, high CEA, CA-19-9 and LDH levels were associated with poorer overall-survival. CEA level was the only independent prognostic factor in multivariate analysis. Coagulation assays can be utilized as predictors of disease extent in CRC. Elevated D-dimer and INR values may indicate higher disease stage. Correlation of D-dimer levels with CEA supports their value for assessing tumor burden.

Citations

Jun 5, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yi ChenAijie Li
Apr 7, 2020·International Journal of Laboratory Hematology·Chanjuan CuiWei Cui
Jun 9, 2017·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Ruyao WangLiling Hu
Dec 5, 2018·World Journal of Gastroenterology : WJG·Hua-Xia CaiShu-Feng Wang

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