D-dimer as marker for microcirculatory failure: correlation with LOD and APACHE II scores

Thrombosis Research
Matthias W A AngstwurmMichael Spannagl

Abstract

The relevance of plasma d-dimer levels as marker for morbidity and organ dysfunction in severely ill patients is largely unknown. In a prospective study we determined d-dimer plasma levels of 800 unselected patients at admission to our intensive care unit. In 91% of the patients' samples d-dimer levels were elevated, in some patients up to several hundredfold as compared to normal values. The highest mean d-dimer values were present in the patient group with thromboembolic diseases, and particularly in non-survivors of pulmonary embolism. In patients with circulatory impairment (r=0.794) and in patients with infections (r=0.487) a statistically significant correlation was present between d-dimer levels and the APACHE II score (P<0.001). The logistic organ dysfunction score (LOD, P<0.001) correlated with d-dimer levels only in patients with circulatory impairment (r=0.474). On the contrary, patients without circulatory impairment demonstrated no correlation of d-dimer levels to the APACHE II or LOD score. Taking all patients together, no correlations of d-dimer levels with single organ failure or with indicators of infection could be detected. In conclusion, d-dimer plasma levels strongly correlated with the severity of the dise...Continue Reading

References

Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
Oct 1, 1995·Thrombosis Research·E Adema, U Gebert
Sep 11, 1996·JAMA : the Journal of the American Medical Association·J R Le GallD Teres
Jun 1, 1996·Journal of Cardiothoracic and Vascular Anesthesia·M E ComunaleL K Robertson
Sep 2, 1998·American Journal of Hematology·M J Carey, G M Rodgers
Dec 28, 1999·The New England Journal of Medicine·E D CarosellaN Rouas-Freiss
Mar 10, 2001·The New England Journal of Medicine·G R BernardUNKNOWN Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group
Nov 15, 2002·Thrombosis Research·E V LugovskoyS V Komisarenko

❮ Previous
Next ❯

Citations

Sep 13, 2015·European Journal of Pediatrics·Julie CayrolRafael Marañón
Aug 12, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Michael SpannaglPiet Meijer
Jul 9, 2008·Annals of Medicine·Giuseppe LippiEmmanuel J Favaloro
Jul 4, 2020·Journal of Thoracic Imaging·Constantine A RaptisEdwin J R van Beek
Oct 27, 2020·Journal of Family Medicine and Primary Care·Satendra KumarAmit Nandan Dhar Dwivedi
Oct 13, 2021·International Journal of Clinical Practice·Aslıhan Gürün KayaAkın Kaya

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.