Abstract
D-dimer, a coagulation-related indicator, has recently been used as a tool for the diagnosis of periprosthetic joint infection (PJI), but its reliability is uncertain. The purpose of this systematic review and meta-analysis was to explore the accuracy of D-dimer in the diagnosis of PJI after joint arthroplasty. We systematically searched the MEDLINE, EMBASE, and Cochrane databases for relevant literature about D-dimer in the diagnosis of PJI. QUADAS-2 was used to assess the risk of bias and clinical applicability of each included study. We used the bivariate meta-analysis framework to pool the sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the SROC curve (AUC). Univariate meta-regression and subgroup analyses were performed to explore the sources of heterogeneity. We included 8 eligible studies. The pooled diagnostic sensitivity and specificity were 0.82 (95% CI, 0.70-0.89) and 0.70 (95% CI, 0.55-0.82), respectively. The pooled PLR, NLR, and DOR were 2.7 (95% CI, 1.7-4.4), 0.26 (95% CI, 0.15-0.46), and 10 (95% CI, 4-25), respectively. The AUC was 0.83 (95% CI, 0.8-0.86). Serum D-dimer might have higher diagnostic accuracy than plasma D-dime...Continue Reading
References
Apr 1, 1990·British Journal of Haematology·M D BoisclairF A Ofosu
Nov 15, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·C F PieperH J Cohen
Oct 2, 2002·Arthritis and Rheumatism·Nathalie Busso, John A Hamilton
Aug 9, 2005·Journal of Clinical Epidemiology·Jonathan J DeeksLes Irwig
Nov 28, 2007·Journal of Clinical Microbiology·C DoraR Zbinden
Nov 15, 2008·Blood·Soheir S AdamCharles S Greenberg
Mar 19, 2009·Annals of Internal Medicine·Levente KristonLars Hölzel
Jun 2, 2009·Seminars in Roentgenology·Ben A Dwamena
Jul 28, 2009·Journal of Clinical Epidemiology·David MoherUNKNOWN PRISMA Group
Jul 2, 2011·Clinical Chemistry·Armando Tripodi
Jul 26, 2011·Journal of Veterinary Internal Medicine·T RiberaM Prades
Sep 23, 2011·Clinical Orthopaedics and Related Research·Javad ParviziCharalampos G Zalavras
Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
May 5, 2012·The Journal of Arthroplasty·Steven M KurtzJavad Parvizi
Jul 17, 2012·The American Journal of Emergency Medicine·Joaquín R RodeloFabián A Jaimes
Sep 18, 2012·Clinical Orthopaedics and Related Research·Keith R BerendMichael A Sneller
Oct 23, 2012·Acta Orthopaedica·Håvard DaleLars B Engesæter
Dec 12, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Douglas R OsmonUNKNOWN Infectious Diseases Society of America
Mar 14, 2013·Expert Opinion on Medical Diagnostics·Dawn M Coleman, Thomas W Wakefield
Jul 19, 2014·Thrombosis Research·Osman TurakZehra Gölbaşı
Mar 31, 2015·Acta Orthopaedica·Kaisa HuotariEsa Jämsen
May 3, 2015·Advances in Clinical Chemistry·John D Olson
May 12, 2015·Thrombosis Research·Mustafa KhanbhaiCharles McCollum
Sep 24, 2015·Atherosclerosis·Wesley T O'NealNeil A Zakai
Nov 21, 2015·European Journal of Internal Medicine·Michael SchwameisBernd Jilma
Dec 23, 2016·Thrombosis and Haemostasis·Neil A ZakaiMary Cushman
Sep 6, 2017·The Journal of Bone and Joint Surgery. American Volume·Alisina ShahiJavad Parvizi
Feb 15, 2018·Journal of Orthopaedic Surgery and Research·Yong Seuk LeeKyung-Hoi Koo
Mar 20, 2018·The Journal of Arthroplasty·Javad ParviziNoam Shohat
Oct 13, 2018·Critical Reviews in Clinical Laboratory Sciences·Gabriel Lima-OliveiraGian Cesare Guidi
Oct 23, 2018·The Journal of Arthroplasty·Noam ShohatWerner Zimmerli
Jan 10, 2019·Frontiers in Neurology·Nicolas Mélé, Guillaume Turc
Mar 7, 2019·The Journal of Arthroplasty·Jun FuJiying Chen
Apr 5, 2019·The Journal of Bone and Joint Surgery. American Volume·Rui LiJi-Ying Chen
Apr 5, 2019·The Journal of Bone and Joint Surgery. American Volume·Alberto V CarliPaul E Beaulé
Jun 4, 2019·The Journal of Arthroplasty·Hong XuFuxing Pei
Jul 31, 2019·Journal of Orthopaedic Surgery and Research·Longjiang XiongMin Dai
Sep 19, 2019·The Journal of Arthroplasty·Leilei QinNing Hu
Dec 1, 2019·Journal of Orthopaedic Surgery and Research·Jincheng HuangYi Jin