D-dimer levels to screen for venous thromboembolism in patients with fractures caused by high-energy injuries

Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association
Takahiro NiikuraMasahiro Kurosaka

Abstract

The clinical relevance of D-dimer levels when screening for venous thromboembolism (VTE) in elderly patients with a hip fracture has been reported but has not been fully investigated in patients with fractures caused by high-energy injuries. The purpose of this study was to evaluate the usefulness and limitations of D-dimer in such patients. We enrolled 80 consecutive patients who underwent surgical treatment for fracture of the pelvis or lower extremity caused by high-energy injuries. None had received pharmacological prophylaxis for VTE. All patients underwent routine ultrasonography preoperatively and postoperatively (average 6.1 days after injury and 7.8 days after surgery). Contrast-enhanced computed tomography was performed routinely at the same time points for patients with a pelvic fracture or multiple fractures. D-dimer levels were compared in patients with and without VTE. Receiver operating characteristic (ROC) curve analysis was done and the appropriate D-dimer cutoff level determined for VTE screening. VTE was diagnosed in 34 of the 80 patients. D-dimer levels were significantly higher in patients with VTE than without it at almost all time points preoperatively and postoperatively except in patients with an isolat...Continue Reading

References

Jun 24, 2005·The Journal of Bone and Joint Surgery. British Volume·J P StannardJ E Alonso
Jul 27, 2005·American Journal of Hematology·Satoshi OtaTakeshi Nakano
Mar 29, 2006·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Motonobu TeraoToru Sato
May 19, 2006·Journal of Thrombosis and Haemostasis : JTH·H WadaT Nobori
Jul 18, 2009·Injury·Thomas PaffrathUNKNOWN Trauma Registry of DGU
Oct 6, 2009·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Satoshi SasakiYoichi Shimada
Feb 5, 2011·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Satoshi SasakiYoichi Shimada
Mar 29, 2012·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Takahiro NiikuraMasahiro Kurosaka
Apr 13, 2012·Lancet·Samuel Z Goldhaber, Henri Bounameaux

❮ Previous
Next ❯

Citations

Apr 19, 2017·Journal of Orthopaedic Surgery·Sang Yang LeeMasahiro Kurosaka
Jan 18, 2019·Acute Medicine & Surgery·Keita IyamaOsamu Tasaki
Sep 30, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Li JiahaoWang Pengfei
Oct 25, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Dariusz GrzeleckiMarcin Tyrakowski
Mar 24, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Peng-Fei WangPing Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.