d-fenfluramine anorexia: dissociation of ingestion rate, meal duration, and meal size effects

Pharmacology, Biochemistry, and Behavior
J M KaplanH J Grill

Abstract

In the present study, we ask whether the suppressive effect of d-fenfluramine (d-FEN) on short-term intake can be better explained in terms of a primary action on particular behavioral parameters (e.g., ingestion rate or meal duration), as proposed by several investigators, or in terms of a primary effect on an intake "target" that can be achieved via diverse behavioral strategies. We applied two specialized intake testing paradigms that constrain the behavioral structure of the rat's meal in different ways, and determined whether or not the meal-size result varied in turn. (1) In the intraoral intake test, the rate of ingestion was clamped by the rate (1.0 ml/min) at which the test stimulus (12.5% glucose) was intraorally delivered. A d-FEN (3 mg/kg) suppression of intraoral intake was obtained demonstrating that ingestion rate adjustment is not necessary for the anorexic effect. In addition, for both d-FEN and vehicle conditions, comparable amounts were consumed when the intraoral intake test was either continuous or interrupted for 10 min beginning 6 min after test onset. For d-FEN, the increase in meal duration (mean = 11.98 min) required to compensate for the imposed interruption indicates that the drug does not specify an...Continue Reading

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Citations

Sep 24, 1999·Pharmacology, Biochemistry, and Behavior·Z J YangG Miyata
Mar 14, 2000·Neuroscience and Biobehavioral Reviews·T A Spiegel
Oct 31, 2000·Nutrition·M M MeguidF Rossi-Fanelli
Jul 28, 1999·Nutrition·M M MeguidA Kubota
Aug 9, 2006·Behavioral Neuroscience·John-Paul BairdShannon G Fischer
Aug 9, 2005·Physiology & Behavior·Cedrick D Dotson, Alan C Spector
Feb 1, 2005·Pharmacology, Biochemistry, and Behavior·Deann P D Atchley, Lisa A Eckel
Mar 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·Koki InoueEric P Zorrilla
Nov 24, 1999·The American Journal of Physiology·U SmedhK Uvnäs-Moberg
Sep 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S EisenG P Smith
Dec 31, 1997·The American Journal of Physiology·J M KaplanH J Grill

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