PMID: 7543929Sep 1, 1995Paper

d-fenfluramine increases striatal extracellular dopamine in vivo independently of serotonergic terminals or dopamine uptake sites

Journal of Neurochemistry
Philippe De DeurwaerdèreUmberto Spampinato

Abstract

The effect of various doses of the serotonin (5-HT) release-inducing agent d-fenfluramine (d-fenf) on extracellular dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and 5-hydroxyindoleacetic acid (5-HIAA) was studied in vivo in the striatum of halothane-anesthetized rats, following systemic and local administration. At 5 and 10 but not 2.5 mg/kg, d-fenf administered intraperitoneally significantly increased DA extracellular concentration and reduced DOPAC outflow. A concentration-dependent enhancement of DA dialysate content was also found following intrastriatal application (5, 10, 25, and 50 microM). The bilateral administration of 5,7-dihydroxytryptamine into the dorsal raphe nucleus, which markedly depleted 5-HT in the striatum, did not modify the effect on extracellular DA concentration of 25 microM d-fenf locally applied into the striatum. The enhancement of extracellular DA level induced by 25 microM d-fenf was slightly but significantly reduced by the local application of 25 microM citalopram. The blockade of DA uptake sites by nomifensine (0.1, 0.3, and 1 microM) did not modify significantly the effect of d-fenf. The rise of DA outflow induced by 25 microM d-fenf was strongly reduced in the presence of 1 microM t...Continue Reading

Citations

Jul 28, 2020·Frontiers in Pharmacology·Giuseppe Di GiovanniPhilippe De Deurwaerdère
Oct 19, 2010·Psychopharmacology·Sylvia Navailles, Philippe De Deurwaerdère
Apr 30, 2014·CNS Neuroscience & Therapeutics·Sylvia NavaillesPhilippe De Deurwaerdère
Jan 8, 2020·International Journal of Molecular Sciences·Abdeslam ChagraouiPhilippe De Deurwaerdère
Jan 21, 2020·Neuropharmacology·Philippe De DeurwaerdèreGiuseppe Di Giovanni
Jan 28, 2019·Neurochemistry International·Abdeslam ChagraouiPhilippe De Deurwaerdère
Jan 1, 1997·Trends in Pharmacological Sciences·G CurzonA O Oluyomi
Jan 4, 2001·Neurochemistry International·V Leviel
Feb 6, 2017·Journal of Neuroscience Methods·Françoise Dellu-HagedornPhilippe De Deurwaerdère
Dec 16, 2016·ACS Chemical Neuroscience·Philippe De DeurwaerdèreJosé Marco-Contelles

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