PMID: 3036613Jan 1, 1987

D-galactosamine induced changes in rat liver plasma membranes lipid composition and some enzyme activities

The International Journal of Biochemistry
D H PetkovaK S Koumanov


The influence of D-galactosamine administration on rat liver plasma membranes lipid composition, fluidity and some enzyme activities was investigated. D-Galactosamine was found to induce an increase of the total phospholipids, the cholesterol level and membrane rigidity. In liver plasma membranes of D-galactosamine-treated rats the exogenous phospholipase A2 activity was enhanced about 2 fold, whereas the endogenous activity was slightly decreased. No alteration of the neutral sphingomyelinase activity was observed.


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