D-glucose modulates synaptic transmission from the central terminals of vagal afferent fibers

American Journal of Physiology. Gastrointestinal and Liver Physiology
Shuxia Wan, K N Browning

Abstract

Experimental evidence suggests that glucose modulates gastric functions via vagally mediated effects. It is unclear whether glucose affects only peripheral vagal nerve activity or whether glucose also modulates vagal circuitry at the level of the brain stem. This study used whole cell patch-clamp recordings from neurons of the nucleus of the tractus solitarius (NTS) to assess whether acute variations in glucose modulates vagal brain stem neurocircuitry. Increasing D-glucose concentration induced a postsynaptic response in 40% of neurons; neither the response type (inward vs. outward current) nor response magnitude was altered in the presence of tetrodotoxin suggesting direct effects on the NTS neuronal membrane. In contrast, reducing d-glucose concentration induced a postsynaptic response (inward or outward current) in 54% of NTS neurons; tetrodotoxin abolished these responses, suggesting indirect sites of action. The frequency, but not amplitude, of spontaneous and miniature excitatory postsynaptic currents (EPSCs) was correlated with d-glucose concentration in 79% of neurons tested (n = 48). Prior surgical afferent rhizotomy abolished the ability of D-glucose to modulate spontaneous EPSC frequency, suggesting presynaptic acti...Continue Reading

References

Sep 1, 1978·The Journal of Physiology·N Mei
Dec 1, 1986·The Journal of Physiology·J ChampagnatK F Shen
Aug 11, 1988·The American Journal of Physiology·A B SteffensS C Woods
Jul 1, 1986·Journal of the Autonomic Nervous System·N Mei, L Garnier
Apr 15, 1985·The Journal of Comparative Neurology·R E Shapiro, R R Miselis
Apr 9, 1985·Neuroscience Letters·A Adachi, M Kobashi
Mar 1, 1968·The Journal of Physiology·B Katz, R Miledi
Sep 20, 1983·The Journal of Comparative Neurology·D van der Kooy, L Y Koda
Jan 1, 1980·Diabetes Care·N G Soler
May 1, 1995·The Journal of Clinical Investigation·M J DuringR S Sherwin
Jan 1, 1994·Annual Review of Physiology·M C Andresen, D L Kunze
Jun 1, 1994·Diabetologia·M Horowitz, R Fraser
Sep 1, 1997·Diabetes·P Enck, T Frieling
Aug 6, 1998·Neuroscience·B A McLaughlinM F Chesselet
Aug 11, 1998·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D V SivaraoP J Hornby
Nov 26, 1999·Neuroreport·M DallaportaJ C Orsini
May 16, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·P J Hornby
Oct 2, 2001·The Journal of Physiology·M FerreiraR A Travagli
Feb 5, 2002·Annual Review of Physiology·Robert S Zucker, Wade G Regehr
Jun 22, 2002·Gut·A C J Windsor
Jul 16, 2002·Physiology & Behavior·Vanessa H Routh
Nov 1, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Helen E RaybouldCatia Sternini
Apr 30, 2003·Diabetes Care·Aaron I VinikRoy Freeman
Jun 27, 2003·Drugs·D Scott Smith, Christopher D Ferris
Jul 19, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Min ShiRichard A Gillis
Dec 23, 2003·Regulatory Peptides·G Trevor Cottrell, Alastair V Ferguson
Apr 6, 2004·Brain Research·Kathleen J S GriffioenDavid Mendelowitz
Jul 12, 2005·Brain Research·V BaptistaR A Travagli
Dec 3, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Denis BurdakovAlexei Verkhratsky
Feb 8, 2006·Annual Review of Physiology·R Alberto TravagliRichard C Rogers
May 6, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·S L FreemanH E Raybould

❮ Previous
Next ❯

Citations

Mar 22, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Shi-Yi ZhouChung Owyang
Dec 15, 2010·Autonomic Neuroscience : Basic & Clinical·Kirsteen N Browning, R Alberto Travagli
Sep 2, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K N Browning, R A Travagli
Aug 1, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T BabicK N Browning
Sep 10, 2014·Journal of Neuroscience Methods·Jason S Nasse
Jun 16, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brandon L RobertsSuzanne M Appleyard
Sep 27, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Parul Chaudhary, Ann M Schreihofer
Sep 20, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Shuxia Wan, Kirsteen N Browning
Dec 17, 2009·The Journal of Physiology·Gintautas GrabauskasChung Owyang
Jun 19, 2015·Journal of Neurophysiology·Carie R BoychukBret N Smith
Feb 20, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrea Mimee, Alastair V Ferguson
Jun 18, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L Ashley Blackshaw, R L Young
Sep 23, 2020·Pflügers Archiv : European journal of physiology·Jong-Woo Sohn, Won-Kyung Ho
Dec 16, 2011·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Arnold Berstad, Jørgen Valeur
Mar 3, 2010·The Journal of Physiology·Kirsteen N Browning
Feb 26, 2019·Scientific Reports·Carie R BoychukBret N Smith
Nov 19, 2015·Frontiers in Neuroscience·Kirsteen N Browning
Nov 19, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Soledad Pitra, Bret N Smith
Mar 19, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Courtney Clyburn, Kirsteen N Browning
Sep 7, 2021·Physiological Reviews·Alan G WattsWolfgang Langhans

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Physiology. Gastrointestinal and Liver Physiology
Shuxia Wan, K N Browning
Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
H E Raybould, T T Zittel
Annual Review of Physiology
R A TravagliR C Rogers
© 2021 Meta ULC. All rights reserved