D-Lactic Acid as a Metabolite: Toxicology, Diagnosis, and Detection.

BioMed Research International
Miroslav Pohanka

Abstract

Two enantiomers of lactic acid exist. While L-lactic acid is a common compound of human metabolism, D-lactic acid is produced by some strains of microorganism or by some less relevant metabolic pathways. While L-lactic acid is an endogenous compound, D-lactic acid is a harmful enantiomer. Exposure to D-lactic acid can happen by various ways including contaminated food and beverages and by microbiota during some pathological states like short bowel syndrome. The exposure to D-lactic acid cannot be diagnosed because the common analytical methods are not suitable for distinguishing between the two enantiomers. In this review, pathways for D-lactic acid, pathological processes, and diagnostical and analytical methods are introduced followed by figures and tables. The current literature is summarized and discussed.

References

Jan 1, 1975·Methods in Enzymology·H B LeJohn, R M Stevenson
May 1, 1981·Journal of Biochemistry·M OgataT Yagi
Jan 1, 1995·Journal of Drug Targeting·E J Lien
Mar 31, 1994·Deutsche medizinische Wochenschrift·S KoletzkoB Koletzko
May 1, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Y S AndersonP Altmann
Aug 3, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R K NarulaP G Schmitz
Dec 6, 2001·Lancet·A D Hingorani, N N Chan
Jun 11, 2002·Journal of Molecular Biology·Adelia RazetoVictor S Lamzin
Nov 19, 2003·International Journal of Food Microbiology·Kanta Sakamoto, Wil N Konings
Nov 27, 2004·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·David R Mack
Jun 2, 2005·Biotechnology Letters·Hyun-A LimYutaka Tokiwa
Nov 25, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Craig Petersen
Apr 8, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Vincent SapinBertrand Souweine
Nov 23, 2006·Critical Care : the Official Journal of the Critical Care Forum·Vibeke L JørgensenAnders Perner
Feb 22, 2007·The Journal of Nutrition·Maya Pineiro, Catherine Stanton
May 17, 2007·American Journal of Physiology. Endocrinology and Metabolism·Saman AbeysekaraGordon A Zello
Dec 18, 2008·Annals of Nutrition & Metabolism·Elisabeth Haschke-BecherClaude Bachmann
Nov 18, 2009·Brain & Development·Shun MunakataHideo Mugishima
Nov 3, 2010·Applied Biochemistry and Biotechnology·So Hee Lee, Wha Soon Song
Dec 6, 2011·Chemical Society Reviews·Mingxi ZhangTaolei Sun
Jul 13, 2013·Nature Communications·Yanliang WangHuilin Wan
Oct 2, 2013·Mayo Clinic Proceedings·Lars W AndersenMichael W Donnino
May 27, 2015·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Miroslav Pohanka
Aug 13, 2015·Journal of Pharmaceutical and Biomedical Analysis·Chien-Ming ChenHan-Yin Yu
Sep 24, 2015·International Journal of Food Microbiology·Andreas J GeisslerRudi F Vogel
Dec 25, 2015·The Journal of Sports Medicine and Physical Fitness·T SunH Ma
Apr 14, 2016·Current Protein & Peptide Science·Ye YangYijun Yao
Oct 11, 2016·Zeitschrift für Gastroenterologie·Elisabeth FabianGuenter J Krejs
Oct 16, 2016·Biomedical Chromatography : BMC·Yu-Shen HuangJen-Ai Lee
Nov 1, 2016·Genome Announcements·Andreas J GeisslerRudi F Vogel
Dec 3, 2016·The Journal of Biological Chemistry·Daniel H PfaffAurelio A Teleman
Jan 13, 2017·Gut Microbes·Luis VitettaSean Hall
Jun 18, 2017·Biochemical and Biophysical Research Communications·Sumi JangChankyu Park
Dec 9, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Davide G A M BianchettiGregorio P Milani
Jan 18, 2018·Folia medica·Raina G ArdashevaAthanas D Krustev

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Citations

Mar 21, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yu YuYanqing Li
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Bin LiAlex C Y Chang
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Anlly Fresno RuedaBenoit St-Pierre
May 25, 2021·Journal of Microbiology and Biotechnology·In Young ChoiMi-Kyung Park
Sep 15, 2021·Journal of Enzyme Inhibition and Medicinal Chemistry·Khalid O AlfaroukStephan J Reshkin
Sep 18, 2021·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Kaori HayashiKenji Manabe

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