D-methionine alleviates cisplatin-induced mucositis by restoring the gut microbiota structure and improving intestinal inflammation

Therapeutic Advances in Medical Oncology
Cheng-Hsi WuChu-Chyn Ou

Abstract

There are close links between chemotherapy-induced intestinal mucositis and microbiota dysbiosis. Previous studies indicated that D-methionine was an excellent candidate for a chemopreventive agent. Here, we investigated the effects of D-methionine on cisplatin-induced mucositis. Male Wistar rats (176-200 g, 6 weeks old) were given cisplatin (5 mg/kg) and treated with D-methionine (300 mg/kg). Histopathological, digestive enzymes activity, oxidative/antioxidant status, proinflammatory/anti-inflammatory cytokines in intestinal tissues were measured. Next-generation sequencing technologies were also performed to investigate the gut microbial ecology. D-methionine administration increased villus length and crypt depth and improved digestive enzyme (leucine aminopeptidase, sucrose and alkaline phosphatase) activities in the brush-border membrane of cisplatin-treated rats (p < 0.05). Furthermore, D-methionine significantly attenuated oxidative stress and inflammatory reaction and increased interleukin-10 levels in cisplatin-induced intestinal mucositis (p < 0.05). Cisplatin administration resulted in high relative abundances of Deferribacteres and Proteobacteria and a low diversity of the microbiota when compared with control groups...Continue Reading

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Citations

Jan 29, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Yi-Sin WongChu-Chyn Ou
Mar 3, 2020·International Journal of Cancer. Journal International Du Cancer·Silvia De PietriKlaus Müller
Feb 20, 2020·International Journal of Molecular Sciences·Elena ConteAntonella Liantonio
Dec 16, 2020·International Journal of Sports Medicine·Fei ZhongCong Huang
Mar 22, 2021·The Science of the Total Environment·Qiang ChuXiaodong Zheng
Jun 24, 2021·Environment International·Guozhu YeQiansheng Huang
Nov 6, 2021·International Journal of Oncology·Xing HuangBole Tian

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Methods Mentioned

BETA
scraping
MDA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

UPGMA
Qiime
UniFrac

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