D-Methionine Ameliorates Cisplatin-Induced Muscle Atrophy via Inhibition of Muscle Degradation Pathway

Integrative Cancer Therapies
Ching-Te WuChu-Chyn Ou

Abstract

Cisplatin induces anorexia, weight loss, loss of adipose tissue, skeletal muscle atrophy, and serious adverse effects that can cause premature termination of chemotherapy. The aim of this study was to use an animal model to assess cisplatin therapy (3 cycles) with and without d-methionine to investigate its protective effects on cisplatin-induced anorexia and skeletal muscle wasting. Wistar rats were divided into 3 groups and treated as follows: saline as control (group 1), intraperitoneal cisplatin once a week for 3 weeks (group 2), and intraperitoneal cisplatin once a week for 3 weeks plus oral administration of d-methionine (group 3). Tissue somatic index (TSI), gastric emptying index (GEI), and feeding efficiency were measured. Both hepatic lipid metabolism and muscle atrophy-related gene expressions and C2C12 myotubes were determined by polymerase chain reaction. Micro-computed tomography (micro-CT) was used to conduct assessment of bone microarchitecture indices. Pathological changes of the gastric mucosa were assessed by hematoxylin and eosin staining after euthanizing the animals. d-Methionine increased food intake, weight gain, gastric emptying, and feeding efficiency, as well as decrease stomach contents, after cispla...Continue Reading

References

Mar 25, 2000·Clinical Genetics·L A Sabourin, M A Rudnicki
Oct 16, 2003·Journal of the American Academy of Audiology·Kathleen Campbell
Dec 23, 2003·The American Journal of Gastroenterology·Christine Feinle-BissetNicholas J Talley
Jul 1, 2005·The Journal of Nutrition·Anna K ShovellerDouglas G Burrin
Mar 10, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H J SchmollC Y Chan
Aug 21, 2007·The Journal of Nutritional Biochemistry·Sonia MétayerSophie Tesseraud
Apr 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Saleha B VuyyuriAlnawaz Rehemtulla
Jun 27, 2008·Autonomic Neuroscience : Basic & Clinical·Pablo Antonio CabezosRaquel Abalo
Nov 19, 2009·Journal of Agricultural and Food Chemistry·Chu-Chyn OuMeei-Yn Lin
Apr 15, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel A HamstraAlnawaz Rehemtulla
Nov 3, 2010·European Journal of Pharmacology·El-Sayed E El-AwadyAsmaa Radwan
Oct 2, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Moon Yong SongJin Soo Han
Apr 19, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R AbaloM I Martín
Dec 18, 2013·Metallomics : Integrated Biometal Science·Melani SooriyaarachchiJürgen Gailer
May 16, 2014·Toxicology and Applied Pharmacology·Hiroyasu SakaiMinoru Narita
Aug 7, 2014·American Journal of Physiology. Endocrinology and Metabolism·Sue C Bodine, Leslie M Baehr
Oct 8, 2014·Nature Reviews. Cancer·Josep M ArgilésFrancisco J López-Soriano
Nov 12, 2014·Journal of Cachexia, Sarcopenia and Muscle·Stephan von Haehling, Stefan D Anker
Jul 3, 2015·Journal of Cachexia, Sarcopenia and Muscle·Ji-An ChenJose M Garcia
Nov 9, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A PiniM G Vannucchi
Aug 24, 2018·Clinical and Experimental Pharmacology & Physiology·Hiroyasu SakaiJunzo Kamei

❮ Previous
Next ❯

Citations

Feb 20, 2020·International Journal of Molecular Sciences·Elena ConteAntonella Liantonio
Jan 5, 2021·Frontiers in Pharmacology·Hong ZhangCheng Guo
Jul 25, 2021·Cancers·Dean G CampeljEmma Rybalka

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

ImageJ

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Related Papers

Journal of Nutritional Science and Vitaminology
Katsuya HirasakaKatsuyasu Tachibana
Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
Ana Belén Gómez-SanMiguelAsunción López-Calderón
© 2022 Meta ULC. All rights reserved