D-Methionine attenuated cisplatin-induced vestibulotoxicity through altering ATPase activities and oxidative stress in guinea pigs

Toxicology and Applied Pharmacology
Po-Wen ChengShoei-Yn Lin-Shiau

Abstract

Cisplatin has been used as a chemotherapeutic agent to treat many kinds of malignancies. Its damage to the vestibulo-ocular reflex (VOR) system has been reported. However, the underlying biochemical change in the inner ear or central vestibular nervous system is not fully understood. In this study, we attempted to examine whether cisplatin-induced vestibulotoxicity and D-methionine protection were correlated with the changes of ATPase activities and oxidative stress of ampullary tissue of vestibules as well as cerebellar cortex (the inhibitory center of VOR system) of guinea pigs. By means of a caloric test coupled with electronystagmographic recordings, we found that cisplatin exposure caused a dose-dependent (1, 3, or 5 mg/kg) vestibular dysfunction as revealed by a decrease of slow phase velocity (SPV). In addition, cisplatin significantly inhibited the Na(+), K(+)-ATPase and Ca(2+)-ATPase activities in the ampullary tissue with a good dose-response relationship but not those of cerebellar cortex. Regression analysis indicated that a decrease of SPV was well correlated with the reduction of Na(+), K(+)-ATPase and Ca(2+)-ATPase activities of the ampullary tissue. D-Methionine (300 mg/kg) reduced both abnormalities of SPV and ...Continue Reading

Citations

Nov 29, 2011·International Journal of Otolaryngology·M E HuthA G Cheng
Oct 17, 2007·Annual Review of Pharmacology and Toxicology·Matthew D HallMichael M Gottesman
Jan 17, 2007·Hearing Research·Kathleen C M CampbellLarry F Hughes
Feb 20, 2020·International Journal of Molecular Sciences·Elena ConteAntonella Liantonio
Apr 25, 2018·Archives of Physiology and Biochemistry·Shereen Mohamed GalalShereen Mohamed El Kiki
Jun 12, 2013·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Masanobu Yoshikawa
Nov 20, 2020·International Journal of Molecular Sciences·Markus LeoTim Hagenacker
May 14, 2021·Archives of Toxicology·Luoying JiangYingzi He
Aug 13, 2021·Frontiers in Neuroscience·Pattarawadee PrayuenyongPeter S Steyger

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