PMID: 9537025Jan 1, 1980Paper

D-penicillamine in vivo enhances lymphocyte DNA synthesis: role of macrophages

Scandinavian Journal of Immunology
L BinderupE Arrigoni-Martelli

Abstract

Administration of D-penicillamine (50 mg/kg/day orally) for 4 days increased the uptake of 3H-thymidine (3H-TdR) in unstimulated and concanavalin-A-stimulated unseparated lymph node and spleen cells from Lewis rats. Increased 3H-TdR incorporation was also found in cultures depleted of adherent cells. D-Penicillamine treatment did not increase the incorporation of 3H-TdR in lymph node and spleen cells from rats concomitantly treated with the selective macrophage toxin silica. In contrast, treatment with D-penicillamine during the last 4 days of silica treatment sometimes resulted in a marked decrease in 3H-TdR incorporation. It is suggested that D-penicillamine treatment in vivo is able to enhance the responsiveness of the lymphocytes, dependent on the presence of functionally intact macrophages. The increased response vanished after 2-3 weeks, even with continuous administration of D-penicillamine.

References

Jan 1, 1979·Acta Pharmacologica Et Toxicologica·E BrammE Arrigoni-Martelli
Jan 1, 1979·Biochemical Pharmacology·L Binderup, E Arrigoni-Martelli
May 1, 1978·British Journal of Pharmacology·F M CunninghamJ R Walker
Apr 1, 1978·Scandinavian Journal of Immunology·L BinderupE Arrigoni-Martelli
Jun 13, 1975·Annals of the New York Academy of Sciences·I A Jaffe
Aug 1, 1966·The Journal of Experimental Medicine·A C AllisonM Birbeck
Mar 1, 1971·American Journal of Clinical Pathology·L T YamW H Crosby

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Citations

Mar 1, 1982·Clinical Rheumatology·L BinderupE Arrigoni-Martelli
Apr 1, 1988·Baillière's Clinical Rheumatology·S R Rudge, D Perrett
Jan 1, 1980·Scandinavian Journal of Immunology·L BinderupE Arrigoni-Martelli
Nov 1, 1981·Arthritis and Rheumatism·G R BurmesterR J Winchester
May 26, 2009·Chemical Research in Toxicology·Jinze LiJack P Uetrecht
Jul 7, 2009·Chemical Research in Toxicology·Jinze Li, Jack P Uetrecht
Nov 1, 1994·Survey of Ophthalmology·D A WeinbergT L Vollmer

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