PMID: 8606345Jan 1, 1995Paper

D-penicillamine inhibits the action of reactive oxygen species in the pig pulmonary circulation

Journal of Perinatal Medicine
J SanderudO D Saugstad

Abstract

Oxygen radicals produced by the hypoxanthine-xanthine oxidase (Hyp-XO) system potently constrict the pulmonary circulation of pigs. D-penicillamine (DPA) is thought to be a free radical scavenger. In the present work we have studied if DPA may influence the vasoactive action of Hyp-XO in pig lungs. Further, we have measured how this drug influences the output of cyclooxygenase and lipoxygenase products from the left atrium in pigs infused with XO into the pulmonary circulation. Twelve young pigs were divided into two groups. Group 1, the XO group, was infused 1 U/kg XO into right atrium. Group 2, the DPA group, was pretreated with DPA, 100 mg/kg intravenously before XO infusion as in group 1. Pulmonary artery pressure, left atrial pressure, pulmonary artery blood flow and systemic blood flow and pressure were recorded continuously. Plasma tromboxane B2 and prostaglandin (6-keto-PGF1 alpha) were determined with a radioimmunoassay method. Cysteinyl containing leukotrienes LTC4, LTD4, and LTE4, were measured together by RIA analyses of plasma samples, using a monoclonal antibody. There was a significant parallel decrease in paO2 and saO2 during the 130 minutes duration of the experiments in both groups without differences between ...Continue Reading

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Citations

Feb 9, 2000·Pharmacology & Therapeutics·A T Demiryürek, R M Wadsworth
Aug 15, 2009·Pediatric Research·Satyan LakshminrusimhaRobin H Steinhorn
Feb 6, 2008·The Veterinary Clinics of North America. Small Animal Practice·Peter Vajdovich
Oct 21, 2015·Oxidative Medicine and Cellular Longevity·Lajos Lakatos, György Balla
May 27, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·S LakshminrusimhaR H Steinhorn
Aug 5, 2017·Children·Payam Vali, Satyan Lakshminrusimha
Sep 5, 2013·The Cochrane Database of Systematic Reviews·Mosarrat J Qureshi, Manoj Kumar
Feb 17, 2006·Journal of Perinatology : Official Journal of the California Perinatal Association·O D Saugstad
May 7, 2011·Journal of Clinical Pharmacy and Therapeutics·R B Raffa, J V Pergolizzi
Jan 15, 2014·Cell Biochemistry and Function·Deepmala JoshiSunil Kumar Srivastav
Sep 20, 2018·Scientific Reports·Maryam ShahrajabianM Reza Hormozi-Nezhad
Jan 1, 2014·Journal of the American Chemical Society·Roy WeinstainRoger Y Tsien

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