D-psicose, an epimer of D-fructose, favorably alters lipid metabolism in Sprague-Dawley rats

Journal of Agricultural and Food Chemistry
Yasuo NagataKazunari Tanaka

Abstract

D-Psicose, a C3 epimer of D-fructose, is known to lower body weight and adipose tissue weight and affect lipid metabolism. The precise mechanism remains unknown. It has been reported that D-psicose has a short half-life and is not metabolized in the body. To determine how D-psicose modifies lipid metabolism, rats were fed diets with or without 3% D-psicose for 4 weeks. Rats were decapitated without fasting every 6 h over a period of 24 h. Changes in serum and liver lipid levels, liver enzyme activity, and gene expression were quantified in experiment 1. Rats fed D-psicose had significantly lower serum insulin and leptin levels. Liver enzyme activities involved in lipogenesis were significantly lowered by the D-psicose diet, whereas gene expression of a transcriptional modulator of fatty acid oxidation was enhanced. In experiment 2, feeding the D-psicose diet gave significantly lower body weight (389 ± 3 vs 426 ± 6 g, p < 0.05) and food intake (23.8 ± 0.2 vs 25.7 ± 0.4 g/day, p < 0.05) compared to the control diet. Rats fed the D-psicose diet gave significantly higher energy expenditure in the light period and fat oxidation in the dark period compared to rats fed the control diet, whereas carbohydrate oxidation was lower. In sum...Continue Reading

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Citations

Nov 23, 2019·Current Diabetes Reports·Emily Mejia, Michelle Pearlman
May 12, 2016·Current Opinion in Clinical Nutrition and Metabolic Care·Kim-Anne LêOlivier Roger
Sep 25, 2017·Journal of the Science of Food and Agriculture·Yasuo NagataKazunari Tanaka
Feb 14, 2021·Comprehensive Reviews in Food Science and Food Safety·Margaux R Mora, Robin Dando
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nikola MijailovicAziz Aziz
Jun 12, 2021·Food Research International·Shahid MahmoodWanmeng Mu
Jan 22, 2020·Journal of Agricultural and Food Chemistry·Zijie LiXiao-Dong Gao
Nov 6, 2021·Journal of Agricultural and Food Chemistry·Qiang GuoHui-Dong Zheng
Dec 31, 2021·Critical Reviews in Food Science and Nutrition·Wenli ZhangWanmeng Mu

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