D-thyroxine reduces lipoprotein(a) serum concentration in dialysis patients.

Journal of the American Society of Nephrology : JASN
C BommerJ Bommer

Abstract

Uremia raises lipoprotein(a) (Lp(a)) serum concentration and the risk of arteriosclerosis in dialysis patients. The treatment of high Lp(a) levels is not satisfactory today. The decrease of Lp(a) in hypothyroid patients on L-T4 therapy raised the question of whether dextro-thyroxine (D-thyroxine) reduces not only serum cholesterol, but also Lp(a) serum concentration. In a single-blind placebo-controlled study, the influence of D-thyroxine therapy on Lp(a) serum concentration was evaluated in 30 hemodialysis patients with elevated Lp(a) serum levels. Lp(a) was quantified in parallel by two methods, i.e., rocket immunoelectrophoresis and nephelometry, and apo(a) isoforms were determined by a sensitive immunoblotting technique. Regardless of the apo(a) isoforms, 6 mg/d D-thyroxine reduced elevated Lp(a) levels significantly by 27 +/- 13% in 20 dialysis patients (P < 0.001) compared with 10 control subjects (-9.9 +/- 8.4%). In parallel, D-thyroxine therapy significantly lowered total cholesterol (P < 0.001), LDL cholesterol (P < 0.001), and LDL cholesterol/HDL cholesterol ratio (P < 0.01); raised T4 and T3 serum levels; and suppressed thyroid-stimulating hormone secretion without causing clinical symptoms of hyperthyroidism in any ...Continue Reading

Citations

Nov 10, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Z A Massy
Mar 19, 2014·The International Journal of Artificial Organs·Periklis DousdampanisCostas Fourtounas
Mar 9, 2021·International Urology and Nephrology·Juliane PetersVassilios Liakopoulos
May 10, 2002·Pediatric Transplantation·Uwe Querfeld, Friederike Wahn
Jun 16, 2006·Kidney International·C ZoccaliP Pizzini
Sep 5, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity·Angélica Amorim AmatoFrancisco de Assis Rocha Neves

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
A T WebbE A Brown
Cardiovascular Journal of South Africa : Official Journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners
Rhena DelportHans G Kraft
© 2021 Meta ULC. All rights reserved