d-Xylose concentration-dependent hydrolase expression profiles and the function of CreA and XlnR in Aspergillus niger.

Applied and Environmental Microbiology
Astrid R Mach-AignerL H de Graaff

Abstract

Aspergillus niger is an important organism for the production of industrial enzymes such as hemicellulases and pectinases. The xylan-backbone monomer, d-xylose, is an inducing substance for the coordinate expression of a large number of polysaccharide-degrading enzymes. In this study, the responses of 22 genes to low (1 mM) and high (50 mM) d-xylose concentrations were investigated. These 22 genes encode enzymes that function as xylan backbone-degrading enzymes, accessory enzymes, cellulose-degrading enzymes, or enzymes involved in the pentose catabolic pathway in A. niger. Notably, genes encoding enzymes that have a similar function (e.g., xylan backbone degradation) respond in a similar manner to different concentrations of d-xylose. Although low d-xylose concentrations provoke the greatest change in transcript levels, in particular, for hemicellulase-encoding genes, transcript formation in the presence of high concentrations of d-xylose was also observed. Interestingly, a high d-xylose concentration is favorable for certain groups of genes. Furthermore, the repressing influence of CreA on the transcription and transcript levels of a subset of these genes was observed regardless of whether a low or high concentration of d-xyl...Continue Reading

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Citations

Apr 3, 2014·Biotechnology for Biofuels·Ana Cristina ColabardiniGustavo Henrique Goldman
May 6, 2014·Fungal Genetics and Biology : FG & B·Jolanda M van MunsterDavid B Archer
Apr 25, 2012·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Jimmy OmonyAnton J B van Boxtel
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Mar 31, 2015·Biochemical and Biophysical Research Communications·Zhen-Bang HuangZhi-Yang Dong
Dec 17, 2016·PLoS Genetics·Jasper SloothaakJuan Antonio Tamayo-Ramos
Jan 4, 2018·International Journal of Molecular Sciences·Muhammad AdnanGuodong Lu
Mar 28, 2016·Genetics·Laure N A RiesGustavo H Goldman
Jun 16, 2017·Biotechnology for Biofuels·Tiziano BenocciRonald P de Vries
Jul 25, 2017·Current Microbiology·Prakriti Sharma Ghimire, Cheng Jin
Oct 16, 2018·Frontiers in Bioengineering and Biotechnology·Ebru Alazi, Arthur F J Ram
Oct 4, 2018·Frontiers in Bioengineering and Biotechnology·Glaucia Emy Okida MidorikawaRobert Neil Gerard Miller
May 6, 2021·Applied Microbiology and Biotechnology·Audrey MasiAstrid R Mach-Aigner

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