PMID: 11313297Apr 21, 2001Paper

D(1) dopamine receptors potentiate nmda-mediated excitability increase in layer V prefrontal cortical pyramidal neurons

Cerebral Cortex
J Wang, Patricio O'Donnell

Abstract

The interactions between N-methyl-D-aspartate (NMDA) and D(1) dopamine receptors in the rat prefrontal cortex were examined using whole-cell recordings from pyramidal neurons. The effects of NMDA, the D(1) agonist SKF38393, or both compounds combined were tested on measures of cell excitability. Both NMDA (10-100 microM) and SKF38393 (5-10 microM) independently increased the number of spikes and decreased the latency of the first spike evoked by intracellular depolarizing current pulses. Combining low doses of NMDA (5 microM) and SKF38393 (2 microM) resulted in a marked increase of cell excitability. This synergism was blocked by SCH23390, protein kinase A (PKA) inhibitors, and the Ca(2+) chelator BAPTA, and reduced by nifedipine. These results indicate the presence of a dopamine- glutamate interaction in the prefrontal cortex at the postsynaptic level, by which D(1) dopamine receptors may maintain NMDA- mediated responses in prefrontal cortical pyramidal neurons through both a PKA-dependent pathway and Ca(2+)-dependent mechanisms.

Citations

May 24, 2007·Molecular Neurobiology·Xiu-Ti Hu
Jul 8, 2005·Psychopharmacology·Christopher J MacDonald, Warren H Meck
May 4, 2006·Psychopharmacology·Stan B Floresco, Orsolya Magyar
Nov 7, 2006·Psychopharmacology·Christopher C LapishJeremy K Seamans
Feb 13, 2010·Neurotoxicity Research·Patricio O'Donnell
Jan 27, 2004·Brain Research. Developmental Brain Research·Steven A LloydRichard J Smeyne
Jul 26, 2003·Progress in Neurobiology·Thérèse M Jay
Dec 25, 2003·Neural Networks : the Official Journal of the International Neural Network Society·F Gregory Ashby, Michael B Casale
Jan 27, 2009·Nature Neuroscience·Kyriaki SidiropoulouDonald C Cooper
Jul 30, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Shao-Pii OnnAnthony A Grace
Jul 28, 2009·Cognitive Neuropsychiatry·Hao-Yang TanDaniel R Weinberger
May 24, 2012·Cerebral Cortex·Sebastian HeinzelAnn-Christine Ehlis
May 18, 2007·Acta Pharmacologica Sinica·Wei-Hua GuXue-Chu Zhen
May 4, 2006·Science's STKE : Signal Transduction Knowledge Environment·Carlos Cepeda, Michael S Levine
Aug 23, 2002·Journal of Cognitive Neuroscience·Jean-Claude DreherYves Burnod
May 10, 2012·PLoS Computational Biology·Kyriaki Sidiropoulou, Panayiota Poirazi
Aug 3, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hannah J Seong, Adam G Carter
Jan 30, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Michal KrawczykEric C Dumont
Jul 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hao-Yang TanJoseph H Callicott
May 13, 2014·Journal of Neural Transmission·Susanna WatersNicholas Waters

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