D₁-NMDA receptor interactions in the rat nucleus accumbens change during adolescence

Synapse
Frederic Huppe-Gourgues, Patricio O'Donnell

Abstract

Many aspects of the dopamine (DA) system mature during adolescence. For example, the DA modulation of glutamate responses in the rat prefrontal cortex (PFC) acquires adult characteristics during late adolescence. In the striatum, D₁ receptors modulate NMDA responses, but whether this behaviorally important interaction matures during adolescence is not known. Here, we tested whether the D₁ agonist SKF38393 affects NMDA actions on nucleus accumbens medium spiny neuron (MSN) excitability in slices from juvenile and young adult rats. NMDA dose-dependently increased excitability in both age groups, and the D₁ agonist produced a marginal increase of MSN excitability. In juvenile slices, the most common interaction was a downregulation of NMDA effects on excitability by the D₁ agonist, whereas in most adult MSN, the D₁ agonist increased NMDA effects on MSN excitability. These results suggest that D₁-NMDA receptor interactions in the nucleus accumbens change during adolescence, a change that may result in different processing of reward functions during this critical developmental stage.

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Citations

Jun 13, 2013·Behavioural Brain Research·Emily R HankoskyJoshua M Gulley
Apr 11, 2013·Psychopharmacology·Leora YetnikoffCecilia Flores
May 29, 2015·The Journal of Physiology·Menglu YuanFrances M Leslie
Jun 19, 2014·Molecular Neurobiology·Ti-Fei Yuan, Gonglin Hou
Nov 12, 2013·Drug and Alcohol Dependence·R E FeatherstoneS J Siegel
Feb 7, 2018·Nature Communications·Hideaki YanoSergi Ferré
Aug 29, 2013·The Journal of Comparative Neurology·Leora YetnikoffDaniel S Zahm
Jul 15, 2016·Journal of Psychopharmacology·Aung Aung Kywe MoeDarryl W Eyles
Jan 31, 2021·Pharmacology, Biochemistry, and Behavior·M L Shawn Bates, Keith A Trujillo
Oct 17, 2017·Trends in Neurosciences·Daniel Hoops, Cecilia Flores

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