PMID: 1194159Oct 1, 1975Paper

D2 18O (deuterium oxide) method for CO2 output in small mammals and economic feasibility in man

Journal of Applied Physiology
N LifsonR M Henderson

Abstract

A test of the validity of the isotopic steady state relationships of the doubly labeled water (H2O) method has been carried out with D2 18O in small mammals (three chipmunks and one mouse). CO2 outputs calculated just from 1) the rate of water intake and 2) the ratios of the isotopic concentrations in the body water to the intake water agreed satisfactorily with observed values. Moreover, reconstructed energy and material balances agreed reasonably with similar balances reconstructed for an immediately succeeding period on the same animals studied by the previously validated decay procedure. We conclude from an error analysis that by expressing the isotopic specific activities as abundances in excess of the body water of a subject on a given regimen, the decay procedure is economically feasible in the human with available accuracy of isotopic analyses and the present cost of H2 18O. The method therefore appears to be a useful tool ready for application to the field of human energy metabolism.

Citations

Feb 25, 1988·The New England Journal of Medicine·S B RobertsA Lucas
Nov 17, 2016·European Journal of Clinical Nutrition·Y Y Lam, E Ravussin
May 17, 2017·European Journal of Applied Physiology·Klaas R Westerterp
Jul 20, 2011·Mass Spectrometry Reviews·Henk SchierbeekJohannes B van Goudoever
Jan 11, 2012·Endocrine Journal·Yukiko NishimotoShuichi Miyatani
Nov 15, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Vincent CareauMurray M Humphries
Mar 18, 2006·Isotopes in Environmental and Health Studies·John R Speakman
Dec 15, 2010·Rapid Communications in Mass Spectrometry : RCM·Thomas ThorsenDale A Schoeller
Oct 14, 2017·Rapid Communications in Mass Spectrometry : RCM·Yue RuanMichelle Venables
May 1, 1994·The American Journal of Physiology·W N LeeL O Byerley
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