D2-40 antibody immunoreactivity in developing human brain, brain tumors and cultured neural cells

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Y NakamuraMami Yamasaki

Abstract

D2-40 antibody is raised against an oncofetal antigen, the M2A antigen. It has been used as a marker for lymphatic endothelium as well as mesothelioma and cerebellar hemangioblastoma. We demonstrate here that positive D2-40 immunoreactivity was found in the developing cerebrum, particularly in the germinal matrix layer, immature ependyma, choroid plexus and meninges. In the developing cerebellum, positive D2-40 immunoreactivity was found in the external granular layer particularly of the outer portion and the Purkinje cell layer as well as meninges. Some brain tumors such as anaplastic ependymoma, some medulloblastomas, glioblastoma, pineal germinoma, craniopharyngioma, choroid plexus papilloma, choroid plexus carcinoma, and meningioma showed positive immunoreactivity with D2-40. Therefore, D2-40 antibody is considered a useful marker for research on developing brain and diagnosis of brain tumors, differentiation between choroid plexus carcinoma and metastatic carcinoma. In addition, on cultured human neural cells, D2-40 immunoreactivity was found in nestin-positive neural stem/progenitor cells and neuronal lineage cells. As D2-40 antibody recognizes cell surface antigen M2A, it might be a candidate cell surface marker for isol...Continue Reading

References

Jan 1, 1992·Cell Motility and the Cytoskeleton·R A Nixon, T B Shea
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D BaileyA Marks
Apr 16, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Harriette J KahnAlexander Marks
Sep 10, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Harriette J Kahn, Alexander Marks
Jan 22, 2003·Advanced Drug Delivery Reviews·Haiying SunWilliam F Elmquist
Apr 16, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yasuhiro NakamuraHideyuki Okano
May 30, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mübeccel AkdisCezmi A Akdis
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wandong ZhangDanica B Stanimirovic
Jul 13, 2004·Molecular Neurobiology·Dragan Maric, Jeffery L Barker
Aug 7, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·William W L ChoiAndrew N Young
Sep 25, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Albert Y ChuPaul J Zhang
Oct 7, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kimberly L DumoffGeza Acs
Oct 27, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Masanori AiharaToshiyuki Takeuchi
Feb 3, 2005·Stem Cells and Development·J MokrýD English
Apr 5, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yasuhiro NakamuraHideyuki Okano
Apr 7, 2005·Neuroscience Research·Mohammed Omedul IslamJun Miyake
May 28, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Larisa V DebelenkoHarry P W Kozakewich
Jun 14, 2005·FEBS Letters·Mohammed Omedul IslamHideyuki Okano

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Citations

Apr 29, 2010·Brain Tumor Pathology·Masayuki ShintakuTomomi Sakai
Apr 9, 2010·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Andreana L RiveraSuzanne Z Powell
Jul 6, 2014·BioMed Research International·Eman Abdelzaher, Dina Mohamed Abdallah
Oct 21, 2015·World Neurosurgery·Hiroaki MatsumotoKozo Yoshida
Apr 21, 2012·Neuroscience Letters·B O PopescuL M Popescu
Nov 18, 2015·American Journal of Clinical Pathology·E Kelly S MrachekB K Kleinschmidt-DeMasters
Jul 29, 2010·Genes, Chromosomes & Cancer·Maria Angelica CortezGeorge Adrian Calin
Jan 13, 2015·Annals of Clinical and Translational Neurology·Lorelei D ShoemakerSteven D Chang
Aug 20, 2014·Experimental Eye Research·Martina C HerwigAnnette M Müller
Jun 18, 2020·Surgical Neurology International·Anil K MahavadiHarminder Singh
Dec 25, 2010·Journal of Neuro-oncology·Karina ChristensenBjarne Winther Kristensen

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