D2 dopamine receptor regulation of learning, sleep and plasticity

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
A S C FrançaSidarta Ribeiro

Abstract

Dopamine and sleep have been independently linked with hippocampus-dependent learning. Since D2 dopaminergic transmission is required for the occurrence of rapid-eye-movement (REM) sleep, it is possible that dopamine affects learning by way of changes in post-acquisition REM sleep. To investigate this hypothesis, we first assessed whether D2 dopaminergic modulation in mice affects novel object preference, a hippocampus-dependent task. Animals trained in the dark period, when sleep is reduced, did not improve significantly in performance when tested 24h after training. In contrast, animals trained in the sleep-rich light period showed significant learning after 24h. When injected with the D2 inverse agonist haloperidol immediately after the exploration of novel objects, animals trained in the light period showed reduced novelty preference upon retesting 24h later. Next we investigated whether haloperidol affected the protein levels of plasticity factors shown to be up-regulated in an experience-dependent manner during REM sleep. Haloperidol decreased post-exploration hippocampal protein levels at 3h, 6h and 12h for phosphorylated Ca(2+)/calmodulin-dependent protein kinase II, at 6h for Zif-268; and at 12h for the brain-derived n...Continue Reading

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Citations

Apr 10, 2016·Behavioural Brain Research·Arthur S C FrançaBruno Lobão-Soares
Jun 24, 2015·Journal of Cognitive Neuroscience·John GroganElizabeth Coulthard
Jul 29, 2018·Cellular and Molecular Life Sciences : CMLS·Daniel G Almeida-FilhoSidarta Ribeiro
Sep 14, 2018·Frontiers in Behavioral Neuroscience·Bruno Lobao-SoaresAna Carolina Luchiari
Apr 12, 2019·Scientific Reports·Gustavo Zampier Dos Santos LimaPlamen Ch Ivanov
Nov 11, 2020·Neuroscience and Biobehavioral Reviews·Salar VaseghiMohammad-Reza Zarrindast
Sep 29, 2020·Heliyon·Arthur S C FrançaMichael X Cohen
Feb 3, 2018·Neuroscience and Biobehavioral Reviews·Sarah LyNirinjini Naidoo

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