D2-mediated modulation of N-type calcium currents in rat globus pallidus neurons following dopamine denervation

The European Journal of Neuroscience
Alessandro StefaniGiorgio Bernardi

Abstract

We have studied the effects of dopamine and the D2-like agonist quinpirole on calcium currents of neurons isolated from the striatum and the globus pallidus (GP). Experiments were performed in young adult rats, either in control conditions or following lesion of the nigrostriatal pathway by the unilateral injection of 6-hydroxydopamine (6-OHDA) in the substantia nigra. Apomorphine-driven contralateral turning, 15 days after lesioning, assessed the severity of the dopamine denervation. In addition, the loss of tyrosine hydroxylase immunohistochemistry confirmed the extent of the toxin-induced damage. In both striatal medium spiny (MS) and GP neurons of control animals dopamine and quinpirole promoted a very modest inhibition of calcium conductance. Following 6-OHDA, the inhibition was unaltered in MS (from 10 to 12%), but significantly augmented in GP neurons (21% vs. 9%). Interestingly, analogous inhibition was observed in GP neurons dissociated 20 h after reserpine treatment. Further features of the D2 response were thus studied only in neurons isolated from 6-OHDA-lesioned GP. The D2 modulation was G-protein-mediated but not strictly voltage-dependent. omega-Conotoxin-GVIA occluded the response implying the involvement of N-t...Continue Reading

References

Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Dec 1, 1968·European Journal of Pharmacology·U Ungerstedt
Apr 13, 1984·European Journal of Pharmacology·D A BergstromJ R Walters
Apr 22, 1982·Brain Research·D A BergstromJ R Walters
Jan 1, 1994·Annual Review of Neuroscience·C Tanaka, Y Nishizuka
Oct 1, 1996·Trends in Neurosciences·M F Chesselet, J M Delfs
Dec 3, 1999·The European Journal of Neuroscience·A StefaniG Bernardi
Dec 14, 1999·Behavioural Brain Research·W Hauber, S Lutz
Dec 22, 1999·Journal of Neurophysiology·D CentonzeG Bernardi
Feb 29, 2000·The Journal of General Physiology·C F Barrett, A R Rittenhouse
Feb 13, 2001·Experimental Neurology·M B HarrisonJ M Trugman
Feb 13, 2001·Molecular and Cellular Probes·G GrecoD Buonavoglia
Apr 21, 2001·Journal of Neural Transmission·A GalvanJ Aceves

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Citations

Apr 19, 2007·The European Journal of Neuroscience·Camila L ZoldM Gustavo Murer
May 31, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Naomi M WarrenDavid J Burn

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