D(2) receptors receive paracrine neurotransmission and are consistently targeted to a subset of synaptic structures in an identified neuron of the crustacean stomatogastric nervous system.

The Journal of Comparative Neurology
Max F OginskyDeborah J Baro

Abstract

Dopamine (DA) modulates motor systems in phyla as diverse as nematodes and arthropods up through chordates. A comparison of dopaminergic systems across a broad phylogenetic range should reveal shared organizing principles. The pyloric network, located in the stomatogastric ganglion (STG), is an important model for neuromodulation of motor networks. The effects of DA on this network have been well characterized at the circuit and cellular levels in the spiny lobster, Panulirus interruptus. Here we provide the first data about the physical organization of the DA signaling system in the STG and the function of D(2) receptors in pyloric neurons. Previous studies showed that DA altered intrinsic firing properties and synaptic output in the pyloric dilator (PD) neuron, in part by reducing calcium currents and increasing outward potassium currents. We performed single cell reverse transcriptase-polymerase chain reaction (RT-PCR) experiments to show that PD neurons exclusively expressed a type 2 (D(2alphaPan)) DA receptor. This was confirmed by using confocal microscopy in conjunction with immunohistochemistry (IHC) on STG whole-mount preparations containing dye-filled PD neurons. Immunogold electron microscopy showed that surface rece...Continue Reading

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Citations

Jun 17, 2011·Journal of Neurophysiology·Lolahon R KadiriRonald M Harris-Warrick
Jun 25, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aleksander W BalloDirk Bucher
Sep 16, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Edmund W RodgersDeborah J Baro
Oct 14, 2010·Physiology·Amber E HudsonAstrid A Prinz

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